RASGRF1 - Ras protein specific guanine nucleotide releasing factor 1 Gene

Also Known as GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5923

About RASGRF1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,959,906-79,090,780 (from NCBI)

This gene has 9 transcripts (splice variants), 249 orthologues and 24 paralogues. Biased expression in brain (RPKM 10.4) and lung (RPKM 4.4).

Summary

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from Ras protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

RASGRF1 Products (3)

mRNA	Protein	Name
NM_001145648.3	NP_001139120.1	ras-specific guanine nucleotide-releasing factor 1 isoform 3
NM_002891.6	NP_002882.3	ras-specific guanine nucleotide-releasing factor 1 isoform 1
NM_153815.3	NP_722522.1	ras-specific guanine nucleotide-releasing factor 1 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	27856453	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	27856453	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASGRF1 Protein Structure

PH

RhoGEF

RasGEF_N

RasGEF

0
200
400
600
800
1000
1200
1273 a.a.

Protein Preferred Names	Protein Names
ras-specific guanine nucleotide-releasing factor 1	CDC25 like

RASGRF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82705	CDC25 Antibody (YA2450)	WB	Rat
HY-P82705A	CDC25 Antibody (YA2450)(PBS only)	WB	Rat

Related Diseases

Diseases	Alias
Bleeding Disorder, Platelet-Type, 18	Platelet-Type Bleeding Disorder 18 BDPLT18 Bleeding Disorder Due To Calcium- And Dag-Regulated Guanine Exchange Factor-1 Deficiency Bleeding Disorder Due To Caldag-Gefi Deficiency Bleeding Disorder, Platelet Type 18
Myopia	Near-Sightedness Short-Sightedness Nearsightedness Nearsighted Near Vision Close Sighted Myopic Short-Sighted Near Sighted
Degenerative Myopia	Pathological Myopia Myopia, Degenerative Degenerative Progressive High Myopia Progressive High Myopia Progressive High Myopia
Phaeohyphomycosis	Infection By Dematiacious Fungi Phaehyphomycosis Phaeomycosis Pheohyphomycosis Infection By Dematiacious Fungi [Phaehyphomycosis] Dematiaceous Fungal Infection
Transient Neonatal Diabetes Mellitus	Diabetes Mellitus, Transient Neonatal Tndm Chromosome 6-Associated Transient Diabetes Mellitus Dmtn Diabetes Mellitus, 6q24-Related Transient Neonatal Tndm1 Neonatal Diabetes Mellitus, Transient Tndm -[Transient Neonatal Diabetes Mellitus]
Refractive Error	Refractive Errors
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11691	RASGRF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RASGRF1	VGNC	VGNC:45370
Bos taurus	RASGRF1	VGNC	VGNC:33745
Mus musculus	RASGRF1	MGD	MGI:99694
Felis catus	RASGRF1	VGNC	VGNC:69249
Rattus norvegicus	RASGRF1	RGD	RGD:620395
Others	RASGRF1	NCBI