Ptgir - prostaglandin I receptor (IP) Gene

Also Known as IP; PGI2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19222

About Ptgir

Chromosome 7: 16,640,415-16,644,830 forward strand.GRCm39:CM001000.3

This gene has 2 transcripts (splice variants), 187 orthologues, 7 paralogues and is associated with 11 phenotypes. Broad expression in mammary gland adult (RPKM 4.9), spleen adult (RPKM 4.5) and 19 other tissues.

Summary

Predicted to enable prostacyclin receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of platelet-derived growth factor receptor signaling pathway; and negative regulation of smooth muscle cell proliferation. Acts upstream of or within response to lipopolysaccharide. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; gallbladder; genitourinary system; hemolymphoid system gland; and limb segment. Orthologous to human PTGIR (prostaglandin I2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ptgir Products (1)

mRNA Protein Name
NM_008967.3 NP_032993.2 prostacyclin receptor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20622039 MGI
involved in negative regulation of platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20622039 MGI
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
20622039 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
15834430 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ptgir Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (41 - 330)

7tm_GPCRs

7tm_GPCRs: cd14964 (43 - 67)

7tm_GPCRs

7tm_GPCRs: cd14964 (77 - 99)

7tm_GPCRs

7tm_GPCRs: cd14964 (120 - 142)

7tm_GPCRs

7tm_GPCRs: cd14964 (165 - 181)

7tm_GPCRs

7tm_GPCRs: cd14964 (208 - 231)

7tm_GPCRs

7tm_GPCRs: cd14964 (265 - 287)

7tm_GPCRs

7tm_GPCRs: cd14964 (297 - 322)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
Protein Preferred Names Protein Names

prostacyclin receptor

  • PGI receptor

  • PGI2 receptor

  • prostaglandin I2 receptor

  • prostanoid IP receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11386 PTGIR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11387 Ptgir Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11388 Ptgir Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptgir NCBI NCBI:5739