1. Gene
  2. PTGIR - prostaglandin I2 receptor Gene

PTGIR - prostaglandin I2 receptor Gene

Homo sapiens

Also known as IP; PRIPR

Gene ID: 5739 | Gene type: protein coding

About PTGIR

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,610,687-46,625,089 (from NCBI)

This gene has 6 transcripts (splice variants), 187 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 50.8), placenta (RPKM 17.2) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

PTGIR Products(6)

mRNA Protein Name
XR_430206.4
XR_243945.4
XM_005259093.4 XP_005259150.1 prostacyclin receptor isoform X1
XR_935844.3
NM_000960.4 NP_000951.1 prostacyclin receptor
XM_005259095.5 XP_005259152.1 prostacyclin receptor isoform X2

PTGIR Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (30 - 291)

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  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

prostacyclin receptor

PGI receptor

PGI2 receptor

prostaglandin I2 (prostacyclin) receptor (IP)

prostanoid IP receptor

Related Diseases

Diseases Alias
Pulmonary Venoocclusive Disease

Pulmonary Veno-Occlusive Disease

Obstructive Disease Of The Pulmonary Veins

Pvod

Isolated Pulmonary Venous Sclerosis

Venous Form Of Primary Pulmonary Hypertension

Pulmonary Venoocclusive Disease 1, Autosomal Dominant

Pulmonary Valve Insufficiency

Pulmonary Regurgitation

Pulmonary Incompetence

Pulmonary Incompetence, Non-Rheumatic

Pulmonary Insufficiency Following Trauma And Surgery

Pulmonary Regurg.

Pulmonic Insufficiency

Pulmonic Valve Regurgitation

Pulmonary Valve Incompetence

Pulmonary Valve Incompetency

Pulmonary Valvular Insufficiency

Pulmonary Valvular Regurgitation

Pulmonary Valvular Incompetency

Pulmonary Valve Incompetence Nos

Annular Incompetency Pulmonary Valve

Incompetent Pulmonary Valve

Graham Steell Murmur

Pulmonary Valvular Incompetence

Fibromuscular Dysplasia
Erythroleukemia
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus PTGIR VGNC VGNC:49149
Rattus norvegicus PTGIR RGD RGD:1310890
Mus musculus PTGIR MGD MGI:99535
Felis catus PTGIR VGNC VGNC:69145
Canis familiaris PTGIR VGNC VGNC:49027
Macaca mulatta PTGIR VGNC VGNC:76586