PTGIR - prostaglandin I2 receptor Gene

Also Known as IP; PRIPR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5739

About PTGIR

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,610,687-46,625,089 (from NCBI)

This gene has 6 transcripts (splice variants), 187 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 50.8), placenta (RPKM 17.2) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]

PTGIR Products (6)

mRNA	Protein	Name
XR_430206.4
XR_243945.4
XM_005259093.4	XP_005259150.1	prostacyclin receptor isoform X1
XR_935844.3
NM_000960.4	NP_000951.1	prostacyclin receptor
XM_005259095.5	XP_005259152.1	prostacyclin receptor isoform X2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20622039	GOA
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	20622039	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	20622039	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20622039	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGIR Protein Structure

7tm_1

0
100
200
300
386 a.a.

Protein Preferred Names	Protein Names
prostacyclin receptor	PGI receptor PGI2 receptor prostaglandin I2 (prostacyclin) receptor (IP) prostanoid IP receptor

Related Diseases

Diseases	Alias
Pulmonary Venoocclusive Disease	Pulmonary Veno-Occlusive Disease Obstructive Disease Of The Pulmonary Veins Pvod Isolated Pulmonary Venous Sclerosis Venous Form Of Primary Pulmonary Hypertension Pulmonary Venoocclusive Disease 1, Autosomal Dominant
Pulmonary Valve Insufficiency	Pulmonary Regurgitation Pulmonary Incompetence Pulmonary Incompetence, Non-Rheumatic Pulmonary Insufficiency Following Trauma And Surgery Pulmonary Regurg. Pulmonic Insufficiency Pulmonic Valve Regurgitation Pulmonary Valve Incompetence Pulmonary Valve Incompetency Pulmonary Valvular Insufficiency Pulmonary Valvular Regurgitation Pulmonary Valvular Incompetency Pulmonary Valve Incompetence Nos Annular Incompetency Pulmonary Valve Incompetent Pulmonary Valve Graham Steell Murmur Pulmonary Valvular Incompetence
Fibromuscular Dysplasia
Erythroleukemia
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11386	PTGIR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11387	Ptgir Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11388	Ptgir Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTGIR	VGNC	VGNC:49149
Rattus norvegicus	PTGIR	RGD	RGD:1310890
Mus musculus	PTGIR	MGD	MGI:99535
Felis catus	PTGIR	VGNC	VGNC:69145
Canis familiaris	PTGIR	VGNC	VGNC:49027
Macaca mulatta	PTGIR	VGNC	VGNC:76586
Others	PTGIR	NCBI