Arhgdia - Rho GDP dissociation inhibitor (GDI) alpha Gene

Also Known as Gdi-1; RhoDGI; Rho-GDI; RhoGDI-1; rho GDI 1; 5330430M07Rik; Rho GDI alpha; rho-GDI alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 192662

Summary

Enables Rho GDP-dissociation inhibitor activity. Involved in semaphorin-plexin signaling pathway. Acts upstream of or within Rho protein signal transduction and regulation of protein localization. Located in immunological synapse and nucleus. Is expressed in brain and heart. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Arhgdia Products (2)

mRNA Protein Name
NM_001363425.1 NP_001350354.1 rho GDP-dissociation inhibitor 1
NM_133796.8 NP_598557.3 rho GDP-dissociation inhibitor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Rho GDP-dissociation inhibitor activity IDA
IDA: Inferred from direct assay
15093731 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Rho protein signal transduction IDA
IDA: Inferred from direct assay
15093731 MGI
acts upstream of or within regulation of protein localization IDA
IDA: Inferred from direct assay
8939998 MGI
involved in regulation of synaptic vesicle cycle IDA
IDA: Inferred from direct assay
18829665 MGI
involved in regulation of synaptic vesicle cycle IMP
IMP: Inferred from mutant phenotype
18829665 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
20696765 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
18829665 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
18829665 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
11728336 MGI
located in membrane IDA
IDA: Inferred from direct assay
25074804 MGI
located in nucleus IDA
IDA: Inferred from direct assay
25074804 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho GDP-dissociation inhibitor 1

  • Rho GDIalpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180371 NF-115 Inducer / Unkown
HY-RS00943 ARHGDIA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgdia NCBI NCBI:396