Ptprj - protein tyrosine phosphatase, receptor type, J Gene

Also Known as BET; Byp; Scc1; CD148; DEP-1; Ptpb2; RPTPJ; Scc-1; R-PTP-J; PTPbeta2; R-PTP-eta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19271

Summary

Enables protein tyrosine Phosphatase activity. Involved in several processes, including regulation of cell migration; regulation of protein phosphorylation; and regulation of signal transduction. Acts upstream of or within heart development; oligodendrocyte differentiation; and vasculogenesis. Located in immunological synapse and ruffle membrane. Is expressed in midbrain; renal calyx; renal pelvis; and superior colliculus. Human ortholog(s) of this gene implicated in colorectal Cancer. Orthologous to human PTPRJ (protein tyrosine Phosphatase receptor type J). [provided by Alliance of Genome Resources, Apr 2022]

Ptprj Products (2)

mRNA Protein Name
NM_001135657.1 NP_001129129.1 receptor-type tyrosine-protein phosphatase eta isoform 2
NM_008982.6 NP_033008.4 receptor-type tyrosine-protein phosphatase eta isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein tyrosine phosphatase activity IMP
IMP: Inferred from mutant phenotype
12771128 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
18249142 MGI
involved in blood coagulation IMP
IMP: Inferred from mutant phenotype
19246339 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
26063811 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
12588999 MGI
involved in negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
12833140 MGI
involved in negative regulation of T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
12913111 MGI
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
12833140 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12771128 MGI
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26063811 MGI
involved in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
12833140 MGI
involved in negative regulation of signaling receptor activity IMP
IMP: Inferred from mutant phenotype
12771128 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
19139271 MGI
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
26063811 MGI
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway IGI
IGI: Inferred from genetic interaction
18249142 MGI
involved in positive regulation of MAPK cascade IGI
IGI: Inferred from genetic interaction
18249142 MGI
involved in positive regulation of calcium-mediated signaling IGI
IGI: Inferred from genetic interaction
18249142 MGI
involved in positive regulation of cell-matrix adhesion IDA
IDA: Inferred from direct assay
12833140 MGI
involved in positive regulation of macrophage chemotaxis IDA
IDA: Inferred from direct assay
19268662 MGI
involved in positive regulation of peptidyl-tyrosine phosphorylation IGI
IGI: Inferred from genetic interaction
18249142 MGI
involved in positive regulation of phagocytosis IGI
IGI: Inferred from genetic interaction
18249142 MGI
involved in positive regulation of platelet activation IMP
IMP: Inferred from mutant phenotype
19246339 MGI
involved in positive regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
18249142 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
12588999 MGI
Cellular Component GO Annotation Evidence References Source
located in immunological synapse IDA
IDA: Inferred from direct assay
12913111 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
19268662 MGI
located in ruffle membrane IDA
IDA: Inferred from direct assay
19268662 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase eta

  • HPTP beta-like tyrosine phosphatase

  • colon tumor susceptibility 1

  • protein-tyrosine phosphatase eta

  • susceptibility to colon cancer 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18679 Ptprj Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11441 PTPRJ Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25165 Ptprj Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprj NCBI NCBI:5795