Pura - purine rich element binding protein A Gene

Mus musculus

Also known as CAGER-1; ssCRE-BP; Pur-alpha; 6330411E07Rik

Gene ID: 19290 | Gene type: protein coding

About Pura

Summary

Enables several functions, including SMAD binding activity; nucleic acid binding activity; and transcription regulator inhibitor activity. Involved in dendritic transport of messenger ribonucleoprotein complex; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including epithelial cell proliferation; lymphocyte proliferation; and positive regulation of cell population proliferation. Located in several cellular components, including dendrite; neuronal cell body; and nucleus. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 31. Orthologous to human PURA (purine rich element binding protein A). [provided by Alliance of Genome Resources, Apr 2022]

Pura Products(1)

mRNA	Protein	Name
NM_008989.4	NP_033015.1	transcriptional activator protein Pur-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10049721	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15282343	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10318844	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12933792	MGI
enables SMAD binding	IDA IDA: Inferred from direct assay	15282343	MGI
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	15282343	MGI
enables mRNA regulatory element binding translation repressor activity	IDA IDA: Inferred from direct assay	12933792	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12972605	MGI
enables purine-rich negative regulatory element binding	IDA IDA: Inferred from direct assay	12933792	MGI
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	10318844	MGI
enables transcription regulator inhibitor activity	IDA IDA: Inferred from direct assay	10597240	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12972605	MGI
involved in dendritic transport of messenger ribonucleoprotein complex	IDA IDA: Inferred from direct assay	15312650	MGI
involved in dendritic transport of messenger ribonucleoprotein complex	IMP IMP: Inferred from mutant phenotype	15312650	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12972605	MGI
acts upstream of or within lymphocyte proliferation	IMP IMP: Inferred from mutant phenotype	12972605	MGI
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10597240	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15282343	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12933792	MGI
acts upstream of or within nervous system development	IMP IMP: Inferred from mutant phenotype	12972605	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12972605	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12972605	MGI
located in dendrite	IDA IDA: Inferred from direct assay	18495661	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28404748	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	18495661	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	12933792	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12972605	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	28404748	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcriptional activator protein Pur-alpha

purine-rich single-stranded DNA-binding protein alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N10267	Carviolin		/	Unkown
HY-RS11464	PURA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N14807	Neobulgarone A	Inhibitor	/	Unkown
HY-N14808	Neobulgarone B	Inhibitor	/	Unkown
HY-N14809	Neobulgarone C	Inhibitor	/	Unkown
HY-N14810	Neobulgarone D	Inhibitor	/	Unkown
HY-N14812	Neobulgarone E	Inhibitor	/	Unkown
HY-N14814	Neobulgarone F	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pura	NCBI	NCBI:5813

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