NLRC3 - NLR family CARD domain containing 3 Gene

Also Known as NOD3; CLR16.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 197358

About NLRC3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,539,033-3,577,403 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 6.9), spleen (RPKM 4.9) and 23 other tissues.

Summary

This gene encodes a NOD-like Receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

NLRC3 Products (1)

mRNA Protein Name
NM_178844.4 NP_849172.2 NLR family CARD domain-containing protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24560620 GOA
Biological Process GO Annotation Evidence References Source
involved in T cell activation IEP
IEP: Inferred from expression pattern
15705585 GOA
involved in canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
15705585 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
15705585 GOA
involved in negative regulation of NLRP3 inflammasome complex assembly IDA
IDA: Inferred from direct assay
25277106 GOA
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
22863753 GOA
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
25277106 GOA
involved in negative regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
22863753 GOA
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
22863753 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
25277106 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
22863753 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
22863753 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15705585 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
24560620 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLRC3 Protein Structure

NACHT

NACHT: NACHT domain (139 - 304)

LRR_6

LRR_6: Leucine Rich repeat (667 - 687)

LRR_6

LRR_6: Leucine Rich repeat (693 - 715)

LRR_6

LRR_6: Leucine Rich repeat (721 - 743)

LRR_6

LRR_6: Leucine Rich repeat (776 - 799)

LRR_6

LRR_6: Leucine Rich repeat (805 - 825)

LRR_6

LRR_6: Leucine Rich repeat (832 - 854)

LRR_6

LRR_6: Leucine Rich repeat (888 - 910)

LRR_6

LRR_6: Leucine Rich repeat (944 - 967)

LRR_6

LRR_6: Leucine Rich repeat (1001 - 1022)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1036 a.a.
Protein Preferred Names Protein Names

NLR family CARD domain-containing protein 3

  • CARD15-like protein

NLRC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NLRC3 Q7RTR2 PYCARD Homo sapiens Q9ULZ3
Anti Bait CoIP
25277106
Intra
NLRC3 Q7RTR2 PYCARD Homo sapiens Q9ULZ3
Anti Tag CoIP
25277106
Intra
NLRC3 Q7RTR2 PYCARD Homo sapiens Q9ULZ3
Confocal
25277106
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cicatricial Entropion
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0921 Dihydromethysticin 99.71% Unkown
HY-RS09346 NLRC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20066 Nlrc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26570 Nlrc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NLRC3 VGNC VGNC:43843
Macaca mulatta NLRC3 VGNC VGNC:75282
Felis catus NLRC3 VGNC VGNC:63826
Rattus norvegicus NLRC3 RGD RGD:1304902
Mus musculus NLRC3 MGD MGI:2444070
Bos taurus NLRC3 VGNC VGNC:32112
Others NLRC3 NCBI