ELAVL2 - ELAV like RNA binding protein 2 Gene

Also Known as HUB; HELN1; HEL-N1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1993

About ELAVL2

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:23,690,104-23,850,601 (from NCBI)

This gene has 8 transcripts (splice variants), 203 orthologues and 24 paralogues. Biased expression in testis (RPKM 13.9) and brain (RPKM 8.2).

Summary

In humans, the ELAV like RNA binding protein gene family has four members (ELAVL1-4). ELAVL RNA binding proteins recognize AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. The protein encoded by this gene binds to several 3' UTRs, including its own and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and, like ELAVL3 and ELAVL4, is expressed specifically in neurons and primarily localizes to the cytoplasm. This protein also forms a cytosolic complex with the normally nuclear-localized ELAVL1 protein. Alternative splicing of this gene results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Jul 2020]

ELAVL2 Products (41)

mRNA Protein Name
NM_001171195.2 NP_001164666.1 ELAV-like protein 2 isoform b
NM_001171197.2 NP_001164668.1 ELAV-like protein 2 isoform b
NM_001351455.2 NP_001338384.1 ELAV-like protein 2 isoform c
NM_001351456.2 NP_001338385.1 ELAV-like protein 2 isoform d
NM_001351457.2 NP_001338386.1 ELAV-like protein 2 isoform d
NM_001351458.2 NP_001338387.1 ELAV-like protein 2 isoform d
NM_001351459.2 NP_001338388.1 ELAV-like protein 2 isoform d
NM_001351460.2 NP_001338389.1 ELAV-like protein 2 isoform e
NM_001351461.2 NP_001338390.1 ELAV-like protein 2 isoform e
NM_001351462.2 NP_001338391.1 ELAV-like protein 2 isoform f
NM_001351463.2 NP_001338392.1 ELAV-like protein 2 isoform f
NM_001351464.2 NP_001338393.1 ELAV-like protein 2 isoform g
NM_001351465.2 NP_001338394.1 ELAV-like protein 2 isoform g
NM_001351466.2 NP_001338395.1 ELAV-like protein 2 isoform h
NM_001351467.2 NP_001338396.1 ELAV-like protein 2 isoform i
NM_001351468.2 NP_001338397.1 ELAV-like protein 2 isoform i
NM_001351469.2 NP_001338398.1 ELAV-like protein 2 isoform i
NM_001351470.2 NP_001338399.1 ELAV-like protein 2 isoform i
NM_001351471.2 NP_001338400.1 ELAV-like protein 2 isoform i
NM_001351472.2 NP_001338401.1 ELAV-like protein 2 isoform a
NM_001351473.2 NP_001338402.1 ELAV-like protein 2 isoform a
NM_001351474.2 NP_001338403.1 ELAV-like protein 2 isoform a
NM_001351475.2 NP_001338404.1 ELAV-like protein 2 isoform a
NM_001351476.2 NP_001338405.1 ELAV-like protein 2 isoform a
NM_001351477.2 NP_001338406.1 ELAV-like protein 2 isoform b
NM_001351478.2 NP_001338407.1 ELAV-like protein 2 isoform b
NM_001385693.1 NP_001372622.1 ELAV-like protein 2 isoform b
NM_001385694.1 NP_001372623.1 ELAV-like protein 2 isoform j
NM_001385695.1 NP_001372624.1 ELAV-like protein 2 isoform k
NM_001385696.1 NP_001372625.1 ELAV-like protein 2 isoform m
NM_001385697.1 NP_001372626.1 ELAV-like protein 2 isoform c
NM_001385698.1 NP_001372627.1 ELAV-like protein 2 isoform c
NM_001385699.1 NP_001372628.1 ELAV-like protein 2 isoform d
NM_001385700.1 NP_001372629.1 ELAV-like protein 2 isoform e
NM_001385701.1 NP_001372630.1 ELAV-like protein 2 isoform g
NM_001385702.1 NP_001372631.1 ELAV-like protein 2 isoform i
NM_001385703.1 NP_001372632.1 ELAV-like protein 2 isoform a
NM_001385704.1 NP_001372633.1 ELAV-like protein 2 isoform c
NM_001385705.1 NP_001372634.1 ELAV-like protein 2 isoform i
NM_001385707.1 NP_001372636.1 ELAV-like protein 2 isoform d
NM_004432.5 NP_004423.2 ELAV-like protein 2 isoform a

ELAVL2 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (41 - 111)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (127 - 193)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (278 - 347)

  • 0
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  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

ELAV-like protein 2

  • ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)

ELAVL2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811274 HuB Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Hyperinsulinemic Hypoglycemia, Familial, 4

  • Hyperinsulinism Due To Glutamodehydrogenase Deficiency

  • HHF4

  • Familial Hyperinsulinemic Hypoglycemia 4

  • Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency

  • Hyperinsulinism Due To Schad Deficiency

  • Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency

  • Congenital Hyperinsulinism

  • Schad Deficiency

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Phhi

  • 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Myotonic Disease

  • Myotonic Disorders

  • Myotonic Syndrome

  • Symptomatic Myotonia
Myotonic Dystrophy 1

  • Myotonic Dystrophy

  • Dystrophia Myotonica

  • Steinert Disease

  • Myotonic Dystrophy Type 1

  • Myotonia Atrophica

  • DM1

  • Congenital Myotonic Dystrophy

  • Myotonia Dystrophica

  • Steinert Myotonic Dystrophy

  • Dystrophia Myotonica 1

  • Dm

  • Steinert'S Disease

  • Steinert Myotonic Dystrophy Syndrome

  • Myotonic Dystrophy Of Steinert

  • Dystrophia Myotonica Type 1

  • Myotonic Dystrophy Congenital

  • Dystrophy, Myotonic, Type 1

  • Dm - [Dystrophia Myotonica]

  • Myotonic Muscular Dystrophy
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Autosomal Dominant Cerebellar Ataxia

  • Spinocerebellar Ataxia

  • Adca

  • Pierre Marie Cerebellar Ataxia

  • Ataxia, Spinocerebellar

  • Sca

  • Autosomal Dominant Spinocerebellar Ataxia

  • Spinocerebellar Ataxias
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Hereditary Spastic Paraplegia

  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04295 ELAVL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ELAVL2 VGNC VGNC:51712
Macaca mulatta ELAVL2 VGNC VGNC:72201
Rattus norvegicus ELAVL2 RGD RGD:628611
Bos taurus ELAVL2 VGNC VGNC:52768
Mus musculus ELAVL2 MGD MGI:1100887
Felis catus ELAVL2 VGNC VGNC:61802
Others ELAVL2 NCBI