ELK4 - ETS transcription factor ELK4 Gene

Also Known as SAP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2005

About ELK4

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,607,943-205,632,011 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 28 paralogues and is associated with 48 phenotypes. Ubiquitous expression in prostate (RPKM 12.4), lymph node (RPKM 7.6) and 25 other tissues.

Summary

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-Fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

ELK4 Products (2)

mRNA Protein Name
NM_001973.4 NP_001964.2 ETS domain-containing protein Elk-4 isoform a
NM_021795.3 NP_068567.1 ETS domain-containing protein Elk-4 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
20145255 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11846562 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
22722849 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22722849 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22722849 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20145255 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELK4 Protein Structure

Ets

Ets: Ets-domain (5 - 86)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

ETS domain-containing protein Elk-4

  • ELK4, ETS transcription factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04307 ELK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ELK4 VGNC VGNC:40305
Mus musculus ELK4 MGD MGI:102853
Felis catus ELK4 VGNC VGNC:61812
Macaca mulatta ELK4 VGNC VGNC:72211
Rattus norvegicus ELK4 RGD RGD:1310504
Bos taurus ELK4 VGNC VGNC:28434
Others ELK4 NCBI