TRIM65 - tripartite motif containing 65 Gene

Also Known as 4732463G12Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201292

About TRIM65

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,879,537-75,896,951 (from NCBI)

This gene has 7 transcripts (splice variants), 102 orthologues and 80 paralogues. Ubiquitous expression in spleen (RPKM 5.1), lung (RPKM 4.3) and 25 other tissues.

Summary

Predicted to enable zinc ion binding activity. Involved in positive regulation of Autophagy. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TRIM65 Products (2)

mRNA Protein Name
NM_001256124.2 NP_001243053.1 tripartite motif-containing protein 65 isoform 2
NM_173547.4 NP_775818.2 tripartite motif-containing protein 65 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
28594402 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
31310649 GOA
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
26347139 GOA
involved in positive regulation of interferon-beta production IDA
IDA: Inferred from direct assay
28594402 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
31310649 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
28594402 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
34512673 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM65 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (12 - 50)

zf-B_box

zf-B_box: B-box zinc finger (92 - 126)

SPRY

SPRY: SPRY domain (382 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 517 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 65

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N3415 Kumatakenin 99.31% Unkown
HY-RS15065 TRIM65 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRIM65 VGNC VGNC:99565
Bos taurus TRIM65 VGNC VGNC:36347
Mus musculus TRIM65 MGD MGI:2442815
Rattus norvegicus TRIM65 RGD RGD:1559497
Canis familiaris TRIM65 VGNC VGNC:47832
Others TRIM65 NCBI