2. Gene
  3. Selenow - selenoprotein W Gene

Selenow - selenoprotein W Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as selW; Sepw1

Gene ID: 20364 | Gene type: protein coding

About Selenow

Summary

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, and has been shown to function as a glutathione-dependent antioxidant in vivo. Studies in mouse suggest that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. [provided by RefSeq, Apr 2017]

Selenow Products(1)

mRNA Protein Name
NM_009156.2 NP_033182.1 selenoprotein W
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
29615406 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
36336122 MGI
acts upstream of or within response to stress IMP
IMP: Inferred from mutant phenotype
29615406 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

selenoprotein W

selenoprotein W, muscle 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12645 SELENOW Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Selenow NCBI NCBI:6415