Sh3gl1 - SH3-domain GRB2-like 1 Gene

Also Known as EEN; SH3P8; Sh3d2b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20405

Summary

Predicted to enable several functions, including SH3 domain binding activity; beta-1 Adrenergic Receptor binding activity; and enzyme binding activity. Involved in synaptic vesicle uncoating. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in several structures, including central nervous system; chondrocranium; liver; spleen; and testis. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Apr 2022]

Sh3gl1 Products (3)

mRNA Protein Name
NM_001252471.1 NP_001239400.1 endophilin-A2 isoform 2
NM_001357649.1 NP_001344578.1 endophilin-A2 isoform 3
NM_013664.3 NP_038692.1 endophilin-A2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15752756 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endophilin-A2

  • SH3 domain protein 2B

  • SH3 domain-containing GRB2-like protein 1

  • endophilin II

  • endophilin-2

Sh3gl1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sh3gl1 Q62419 Fau Mus musculus P62862
Anti Bait CoIP
19796172
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12836 SH3GL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3gl1 NCBI NCBI:6455