Sorbs1 - sorbin and SH3 domain containing 1 Gene

Also Known as CAP; Sh3d5; SH3P12; mKIAA1296; 2310065E01Rik; 9530001P15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20411

Summary

Enables enzyme binding activity; Insulin Receptor binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including focal adhesion assembly; positive regulation of biosynthetic process; and positive regulation of glucose import. Acts upstream of or within acetylcholine receptor signaling pathway and regulation of skeletal muscle acetylcholine-gated channel clustering. Located in several cellular components, including adherens junction; nuclear matrix; and stress fiber. Part of flotillin complex. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human SORBS1 (sorbin and SH3 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Sorbs1 Products (7)

mRNA	Protein	Name
NM_001034962.1	NP_001030134.1	sorbin and SH3 domain-containing protein 1 isoform 3
NM_001034963.1	NP_001030135.1	sorbin and SH3 domain-containing protein 1 isoform 4
NM_001034964.1	NP_001030136.1	sorbin and SH3 domain-containing protein 1 isoform 5
NM_001403055.1	NP_001389984.1	sorbin and SH3 domain-containing protein 1 isoform 6
NM_001403056.1	NP_001389985.1	sorbin and SH3 domain-containing protein 1 isoform 7
NM_009166.3	NP_033192.2	sorbin and SH3 domain-containing protein 1 isoform 1
NM_178362.1	NP_848139.1	sorbin and SH3 domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables insulin receptor binding	IDA IDA: Inferred from direct assay	9447983	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9447983	MGI
enables protein kinase binding	IDA IDA: Inferred from direct assay	9461600	MGI
enables signaling receptor complex adaptor activity	IPI IPI: Inferred from physical interaction	9447983	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	9447983	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within acetylcholine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	26527617	MGI
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	11001060	MGI
involved in focal adhesion assembly	IDA IDA: Inferred from direct assay	9461600	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	9447983	MGI
involved in positive regulation of D-glucose import	IDA IDA: Inferred from direct assay	11001060	MGI
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	11001060	MGI
involved in positive regulation of glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	11001060	MGI
involved in positive regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	11001060	MGI
involved in positive regulation of lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	11001060	MGI
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	11001060	MGI
acts upstream of or within regulation of skeletal muscle acetylcholine-gated channel clustering	IGI IGI: Inferred from genetic interaction	26527617	MGI
involved in stress fiber assembly	IDA IDA: Inferred from direct assay	9461600	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	10085297	MGI
located in cell-substrate junction	IDA IDA: Inferred from direct assay	10085297	MGI
located in cytoskeleton	IDA IDA: Inferred from direct assay	15777793	MGI
located in cytosol	IDA IDA: Inferred from direct assay	9447983	MGI
part of flotillin complex	IDA IDA: Inferred from direct assay	11001060	MGI
located in membrane	IDA IDA: Inferred from direct assay	9447983	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	11001060	MGI
located in nuclear matrix	IDA IDA: Inferred from direct assay	15777793	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15777793	MGI
located in stress fiber	IDA IDA: Inferred from direct assay	9461600	MGI
located in synapse	IDA IDA: Inferred from direct assay	26527617	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sorbin and SH3 domain-containing protein 1	SH3 domain protein 5 c-Cbl-associated protein ponsin

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13567	SORBS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sorbs1	NCBI	NCBI:10580