Skil - SKI-like Gene

Also Known as sno; Skir; SnoN

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20482

Summary

This gene encodes a member of a small family of proteins that play a key role in the response of cells to extracellular growth signals. The encoded protein regulates members of the transforming growth factor beta signaling pathway. It is highly expressed in certain Cancer cells, where it may have both tumor-suppressing and tumor-promoting roles. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Skil Products (6)

mRNA	Protein	Name
NM_001039090.3	NP_001034179.1	ski-like protein isoform b
NM_001271772.2	NP_001258701.1	ski-like protein isoform c
NM_001398558.1	NP_001385487.1	ski-like protein isoform a
NM_001398559.1	NP_001385488.1	ski-like protein isoform b
NM_001398560.1	NP_001385489.1	ski-like protein isoform b
NM_011386.4	NP_035516.2	ski-like protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	15657445	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12522145	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within blastocyst formation	IMP IMP: Inferred from mutant phenotype	10811619	MGI
acts upstream of cell differentiation	IDA IDA: Inferred from direct assay	17215516	MGI
acts upstream of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	10811619	MGI
acts upstream of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	10811619	MGI
acts upstream of or within lens fiber cell differentiation	IDA IDA: Inferred from direct assay	17215516	MGI
acts upstream of or within lymphocyte homeostasis	IMP IMP: Inferred from mutant phenotype	10811619	MGI
acts upstream of or within negative regulation of cell differentiation	IDA IDA: Inferred from direct assay	17215516	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10811619	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18212064	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	10811619	MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	10811619	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	10811619	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18212064	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	18212064	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ski-like protein	ski-related oncogene ski/sno related

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12970	SKIL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Skil	NCBI	NCBI:6498