Slc12a2 - solute carrier family 12, member 2 Gene

Also Known as Nkcc1; mBSC2; sy-ns; 9330166H04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20496

Summary

Enables potassium ion transmembrane transporter activity. Involved in several processes, including T cell chemotaxis; cellular response to potassium ion; and inorganic ion transmembrane transport. Acts upstream of or within several processes, including cellular ion homeostasis; mammary gland duct morphogenesis; and regulation of secretion by cell. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 78 and middle cerebral artery infarction. Orthologous to human SLC12A2 (solute carrier family 12 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a2 Products (2)

mRNA Protein Name
NM_009194.3 NP_033220.2 solute carrier family 12 member 2
NM_009194.3 NP_033220.2 solute carrier family 12 member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables potassium ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
11940530 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12386165 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell chemotaxis IMP
IMP: Inferred from mutant phenotype
27400149 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
8864124 MGI
acts upstream of or within cell volume homeostasis IMP
IMP: Inferred from mutant phenotype
11940530 MGI
involved in cellular response to chemokine IMP
IMP: Inferred from mutant phenotype
27400149 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
31786261 MGI
involved in cellular response to potassium ion IMP
IMP: Inferred from mutant phenotype
11940530 MGI
involved in chloride transmembrane transport IMP
IMP: Inferred from mutant phenotype
11940530 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
16529873 MGI
involved in inorganic anion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
11940530 MGI
acts upstream of or within intracellular chloride ion homeostasis IMP
IMP: Inferred from mutant phenotype
11940530 MGI
acts upstream of or within intracellular potassium ion homeostasis IMP
IMP: Inferred from mutant phenotype
11940530 MGI
acts upstream of or within intracellular sodium ion homeostasis IMP
IMP: Inferred from mutant phenotype
11940530 MGI
acts upstream of or within maintenance of blood-brain barrier IMP
IMP: Inferred from mutant phenotype
28577991 MGI
acts upstream of or within mammary duct terminal end bud growth IMP
IMP: Inferred from mutant phenotype
12040017 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
12040017 MGI
acts upstream of or within negative regulation of vascular wound healing IMP
IMP: Inferred from mutant phenotype
28577991 MGI
acts upstream of or within positive regulation of aspartate secretion IMP
IMP: Inferred from mutant phenotype
11940530 MGI
involved in potassium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
11940530 MGI
acts upstream of or within regulation of matrix metallopeptidase secretion IMP
IMP: Inferred from mutant phenotype
28577991 MGI
acts upstream of or within regulation of spontaneous synaptic transmission IGI
IGI: Inferred from genetic interaction
25716834 MGI
acts upstream of or within regulation of spontaneous synaptic transmission IMP
IMP: Inferred from mutant phenotype
16227993 MGI
involved in sodium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
11940530 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12386165 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12040017 MGI
located in cell body IDA
IDA: Inferred from direct assay
11940530 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
25716834 MGI
located in cell projection IDA
IDA: Inferred from direct assay
11940530 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
25716834 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 12 member 2

  • basolateral Na-K-Cl symporter

  • bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1

  • bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2

  • sodium/potassium/chloride cotransporters

  • sodium/potassium/chloride transporters

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12997 SLC12A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc12a2 NCBI NCBI:6558