Slc12a2 - solute carrier family 12, member 2 Gene

Mus musculus

Also known as Nkcc1; mBSC2; sy-ns; 9330166H04Rik

Gene ID: 20496 | Gene type: protein coding

About Slc12a2

Summary

Enables potassium ion transmembrane transporter activity. Involved in several processes, including T cell chemotaxis; cellular response to potassium ion; and inorganic ion transmembrane transport. Acts upstream of or within several processes, including cellular ion homeostasis; mammary gland duct morphogenesis; and regulation of secretion by cell. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; lung; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 78 and middle cerebral artery infarction. Orthologous to human SLC12A2 (solute carrier family 12 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a2 Products(2)

mRNA	Protein	Name
NM_009194.3	NP_033220.2	solute carrier family 12 member 2
NM_009194.3	NP_033220.2	solute carrier family 12 member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables potassium ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	11940530	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12386165	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	27400149	MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	8864124	MGI
acts upstream of or within cell volume homeostasis	IMP IMP: Inferred from mutant phenotype	11940530	MGI
involved in cellular response to chemokine	IMP IMP: Inferred from mutant phenotype	27400149	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	31786261	MGI
involved in cellular response to potassium ion	IMP IMP: Inferred from mutant phenotype	11940530	MGI
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	11940530	MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	16529873	MGI
involved in inorganic anion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	11940530	MGI
acts upstream of or within intracellular chloride ion homeostasis	IMP IMP: Inferred from mutant phenotype	11940530	MGI
acts upstream of or within intracellular potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	11940530	MGI
acts upstream of or within intracellular sodium ion homeostasis	IMP IMP: Inferred from mutant phenotype	11940530	MGI
acts upstream of or within maintenance of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	28577991	MGI
acts upstream of or within mammary duct terminal end bud growth	IMP IMP: Inferred from mutant phenotype	12040017	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	12040017	MGI
acts upstream of or within negative regulation of vascular wound healing	IMP IMP: Inferred from mutant phenotype	28577991	MGI
acts upstream of or within positive regulation of aspartate secretion	IMP IMP: Inferred from mutant phenotype	11940530	MGI
involved in potassium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	11940530	MGI
acts upstream of or within regulation of matrix metallopeptidase secretion	IMP IMP: Inferred from mutant phenotype	28577991	MGI
acts upstream of or within regulation of spontaneous synaptic transmission	IGI IGI: Inferred from genetic interaction	25716834	MGI
acts upstream of or within regulation of spontaneous synaptic transmission	IMP IMP: Inferred from mutant phenotype	16227993	MGI
involved in sodium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	11940530	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12386165	MGI
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12040017	MGI
located in cell body	IDA IDA: Inferred from direct assay	11940530	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	25716834	MGI
located in cell projection	IDA IDA: Inferred from direct assay	11940530	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	25716834	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 12 member 2

basolateral Na-K-Cl symporter	bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2	sodium/potassium/chloride cotransporters
sodium/potassium/chloride transporters

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12997	SLC12A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc12a2	NCBI	NCBI:6558

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