Slc4a2 - solute carrier family 4 (anion exchanger), member 2 Gene

Also Known as Ae2; B3RP

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20535

Summary

Enables chloride transmembrane transporter activity. Involved in amelogenesis; chloride transport; and positive regulation of enamel mineralization. Located in basolateral plasma membrane. Is expressed in brain and cornea. Orthologous to human SLC4A2 (solute carrier family 4 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a2 Products (2)

mRNA Protein Name
NM_001253892.1 NP_001240821.1 anion exchange protein 2
NM_009207.3 NP_033233.2 anion exchange protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chloride transmembrane transporter activity IDA
IDA: Inferred from direct assay
17690150 MGI
enables chloride:bicarbonate antiporter activity IDA
IDA: Inferred from direct assay
2371270 MGI
enables chloride:bicarbonate antiporter activity IMP
IMP: Inferred from mutant phenotype
23341620 MGI
Biological Process GO Annotation Evidence References Source
involved in amelogenesis IDA
IDA: Inferred from direct assay
26403673 MGI
involved in chloride transport IDA
IDA: Inferred from direct assay
17690150 MGI
involved in negative regulation of CD8-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
24515893 MGI
involved in negative regulation of CD8-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
24515893 MGI
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
18971331 MGI
involved in positive regulation of enamel mineralization IDA
IDA: Inferred from direct assay
26403673 MGI
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
23341620 MGI
involved in regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
23341620 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
14673081 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
2371270 MGI
located in membrane IDA
IDA: Inferred from direct assay
17690150 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

anion exchange protein 2

  • AE 2

  • anion exchanger 2 type b1

  • anion exchanger 2 type b2

  • anion exchanger 2 type c1

  • anion exchanger 2 type c2

  • band 3-related protein

  • non-erythroid band 3-like protein

  • solute carrier family 4 member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180371 NF-115 Inducer / Unkown
HY-RS13268 SLC4A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc4a2 NCBI NCBI:6522