Slc4a2 - solute carrier family 4 (anion exchanger), member 2 Gene

Mus musculus

Also known as Ae2; B3RP

Gene ID: 20535 | Gene type: protein coding

About Slc4a2

Summary

Enables chloride transmembrane transporter activity. Involved in amelogenesis; chloride transport; and positive regulation of enamel mineralization. Located in basolateral plasma membrane. Is expressed in brain and cornea. Orthologous to human SLC4A2 (solute carrier family 4 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a2 Products(2)

mRNA	Protein	Name
NM_001253892.1	NP_001240821.1	anion exchange protein 2
NM_009207.3	NP_033233.2	anion exchange protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chloride transmembrane transporter activity	IDA IDA: Inferred from direct assay	17690150	MGI
enables chloride:bicarbonate antiporter activity	IDA IDA: Inferred from direct assay	2371270	MGI
enables chloride:bicarbonate antiporter activity	IMP IMP: Inferred from mutant phenotype	23341620	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in amelogenesis	IDA IDA: Inferred from direct assay	26403673	MGI
involved in chloride transport	IDA IDA: Inferred from direct assay	17690150	MGI
involved in negative regulation of CD8-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	24515893	MGI
involved in negative regulation of CD8-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	24515893	MGI
involved in osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	18971331	MGI
involved in positive regulation of enamel mineralization	IDA IDA: Inferred from direct assay	26403673	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23341620	MGI
involved in regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	23341620	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	14673081	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	2371270	MGI
located in membrane	IDA IDA: Inferred from direct assay	17690150	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

anion exchange protein 2

AE 2	anion exchanger 2 type b1
anion exchanger 2 type b2	anion exchanger 2 type c1
anion exchanger 2 type c2	band 3-related protein
non-erythroid band 3-like protein	solute carrier family 4 member 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13268	SLC4A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc4a2	NCBI	NCBI:6522

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