EPO - erythropoietin Gene

Also Known as EP; DBAL; ECYT5; MVCD2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2056

About EPO

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,720,468-100,723,700 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and is associated with 4 phenotypes. Biased expression in liver (RPKM 1.5), endometrium (RPKM 0.5) and 6 other tissues.

Summary

This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of Cancer therapies. [provided by RefSeq, Aug 2017]

EPO Products (1)

mRNA	Protein	Name
NM_000799.4	NP_000790.2	erythropoietin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	9774108	GOA
enables erythropoietin receptor binding	IMP IMP: Inferred from mutant phenotype	28283061	GOA
enables hormone activity	IDA IDA: Inferred from direct assay	9722506	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9774108	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via STAT	IDA IDA: Inferred from direct assay	9722506	GOA
involved in cellular hyperosmotic response	IDA IDA: Inferred from direct assay	14569084	GOA
involved in erythrocyte differentiation	IDA IDA: Inferred from direct assay	15084469	GOA
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	28283061	GOA
involved in erythropoietin-mediated signaling pathway	IDA IDA: Inferred from direct assay	9722506	GOA
involved in erythropoietin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28283061	GOA
involved in negative regulation of calcium ion transport into cytosol	IDA IDA: Inferred from direct assay	14569084	GOA
involved in negative regulation of cation channel activity	IDA IDA: Inferred from direct assay	14569084	GOA
involved in negative regulation of erythrocyte apoptotic process	IDA IDA: Inferred from direct assay	14569084	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	IDA IDA: Inferred from direct assay	14569084	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16497104	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9722506	GOA
involved in positive regulation of Ras protein signal transduction	IDA IDA: Inferred from direct assay	9722506	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9722506	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	14569084	GOA
is active in extracellular space	IDA IDA: Inferred from direct assay	32989016	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	14569084	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPO Protein Structure

EPO_TPO

0
100
193 a.a.

Protein Preferred Names	Protein Names
erythropoietin	epoetin

EPO Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	EPO	P01588	MAN1A1	Homo sapiens	P33908	Anti Tag CoIP	33961781
Intra	EPO	P01588	EPOR	Homo sapiens	P19235	Lumier	29997244
Intra	EPO	P01588	EPHB4	Homo sapiens	P54760	Anti Bait CoIP	26481148
Intra	EPO	P01588	EPHB4	Homo sapiens	P54760	Solid Phase Assay	26481148

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPO Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7164	Erythropoietin/EPO Protein, Human (CHO)	P01588 (A28-R193)	≥ 95%, as determined by reducing SDS-PAGE.

EPO Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83908	EPO Antibody (YA3605)	WB, ICC/IF, ELISA	Human
HY-P83908A	EPO Antibody (YA3605)(PBS only)	WB, ICC/IF, ELISA	Human
HY-P85150	EPO Antibody (YA4842)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Diamond-Blackfan Anemia-Like	DBAL
Erythrocytosis, Familial, 5	ECYT5 Familial Erythrocytosis 5
Microvascular Complications Of Diabetes 2	Microvascular Complications Of Diabetes, Susceptibility To, 2 MVCD2 Diabetic Nephropathy Proliferative Diabetic Retinopathy Proliferative Retinopathy, Diabetic Proliferative Retinopathy, Diabetic, Susceptibility To End-Stage Renal Disease, Diabetic End-Stage Renal Disease, Diabetic, Susceptibility To Diabetic End-Stage Renal Disease
Autosomal Dominant Secondary Polycythemia	Autosomal Dominant Secondary Erythrocytosis
Uremia	Uremia Of Renal Origin
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
Pure Red-Cell Aplasia	Pure Red Cell Aplasia Primary Red Cell Aplasia Red Cell Hypoplasia Prca Red-Cell Aplasia Pure Red-Cell Aplasia, Pure
Acquired Polycythemia	Secondary Polycythemia Polycythemia, Secondary Secondary Erythrocytosis Polycythemia Secondary
Ocular Hypertension	Hypertension, Ocular Intraocular Pressure Increase Oh - [Ocular Hypertension] Oht - [Ocular Hypertension]
Neonatal Anemia	Anemia Neonatal Anemia, Neonatal Anaemia Neonatal Neonatal Anaemia
Iron Deficiency Anemia	Iron-Deficiency Anemia Fe Deficiency Anaemia Ida - [Iron Deficiency Anemia] Fe - [Iron] Deficiency Anemia Nos
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Thrombocytosis	Thrombocythaemia
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Hemangioblastoma	Capillary Hemangioblastoma
Hypertensive Encephalopathy	Encephalopathy, Hypertensive
Primary Polycythemia	Familial Erythrocytosis Familiar Polycythemia Benign Familial Polycythemia Congenital Erythrocytosis Familial Polycythemia Hereditary Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Familial Polycythemia Vera Primary Familial Polycythaemia Primary Inherited Polycythaemia
Refractory Anemia	Anemia Refractory Refractory Anemias Refractory Anemia, Without Ringed Sideroblasts, Without Excess Blasts Refractory Anaemia Without Sideroblasts Refractory Anaemia With Sideroblasts Acquired Idiopathic Sideroblastic Anaemia Primary Acquired Sideroblastic Anaemia Refractory Sideroblastic Anaemia Refractory Anaemia With Excess Blasts Raeb - [Refractory Anaemia With Excess Blasts] Nos Raeb - [Refractory Anaemia With Excess Blasts] Rars-T [Refractory Anaemia With Ringed Sideroblasts Associated With Marked Thrombocytosis]
Rh Isoimmunization	Rh Incompatibility Affecting Management Of Mother
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Erythroleukemia
Ischemia	Acute Coronary Syndrome
Acute Radiation Syndrome	Acute Radiation Sickness
Anemia Of Prematurity
Iritis
Diabetic Neuropathy	Diabetic Neuropathies
Iron Metabolism Disease	Iron Deficiency Iron Disorder Iron Metabolism Disorders Disorder Of Iron Metabolism Iron Fe Deficiency Iron Storage Disease Iron Storage Disorder
Secondary Hyperparathyroidism	Hyperparathyroidism Secondary Hyperparathyroidism, Secondary Secondary Hyperparathyroidism Nec
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Hypersplenism	Hypersplenia Big Spleen Syndrome Hyperfunction Of Spleen Increased Splenic Activity Spleen Metaplasia Splenic Metaplasia
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Calciphylaxis	Idiopathic Calciphylaxis
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Chromosome 5q Deletion Syndrome	5q- Syndrome Mar Myelodysplastic Syndrome Associated With Isolated Del Chromosome Abnormality Macrocytic Anemia, Refractory, Due To 5q Deletion, Somatic 5q Deletion Syndrome 5q Minus Syndrome Refractory Macrocytic Anemia Due To 5q Deletion Myelodysplastic Syndrome With Isolated Del Macrocytic Anemia, Refractory, Due To 5q Deletion 5q- Syndrome, Refractory Macrocytic Anemia Due To 5q Deletion 5q Syndrome Chromosome 5q Deletion Myelodysplastic Syndrome With 5q Deletion Myelodysplastic Syndrome With 5q Deletion Syndrome Anemia, Macrocytic, Refractory, Due To 5q Deletion, Somatic 5q-Syndrome Chromosome 5, Trisomy 5q Loss Of Chromosome 5q 5 Q- Syndrome
Beta-Thalassemia	Beta Thalassemia Cooley'S Anemia Mediterranean Anemia Beta Thalassemia Intermedia Erythroblastic Anemia Thalassemia, Hispanic Gamma-Delta-Beta Thalassemia Major Thalassemia Minor Beta-Plus-Thalassemia Thalassemia, Beta Beta Thalassemia Major Beta Thalassemia Minor Thalassemias, Beta- Microcytemia, Beta Type Thalassemia, Beta Type B-THAL Mediterranean Anaemia Beta Thalassaemia Syndrome Mediterranean Disease Beta Thalassaemia Disease
Hyperparathyroidism	Hyperparathyroidism And Other Disorders Of Parathyroid Gland Parathyroid Hyperfunction Hpth - [Hyperparathyroidism] Parathyroid Gland Hyperfunction Parathyroid Glandular Hyperfunction
Thalassemia	Sickle-Cell Thalassemia With Crisis Sickle-Cell Thalassemia Without Crisis Thalassemia Hb-S Disease With Crisis Thalassemia Hb-S Disease Without Crisis Thalassemias Hereditary Leptocytosis Haemoglobin Thalassaemia Disorder Thalassaemia Syndrome Thalassaemia Nos Thalassemia Variants
Pancytopenia
Sickle Cell Anemia	Hemoglobin Sc Disease Anemia, Sickle Cell Hbsc Disease Sickle Cell-Hemoglobin C Disease Syndrome Hb Ss Disease Sickle Cell Trait Drepanocytosis Haemoglobin Sc Disease Hb Sc Disease Hb-S/Hb-C Disease Hb-Ss Disease Without Crisis Hemoglobin S Disease Without Crisis Sickle Cell Anaemia Sickle-Cell/Hb-C Disease Without Crisis Sickle Cell - Hemoglobin C Disease Hbs Disease Hemoglobin S Disease Sickling Disorder Due To Hemoglobin S SKCA Sickle Cell Disease Sickle Cell-Hemoglobin C Disease Sickle-Cell Disease Carrier Sickle-Cell Heterozygous Disorder Haemoglobin A-S Genotype Hb-S - [Sickle Cell Haemoglobin] Carrier Sickle Cell Haemoglobin Trait As - [Sickle Cell Trait] Hbas - [Sickle Cell Haemoglobin Trait] Sickle-Cell Trait Haemoglobin Disease Haemoglobin Sickle Cell Trait Disorder Heterozygous Sickle Cell Trait Hbas - [Heterozygous Haemoglobin S]
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Porphyria Cutanea Tarda	Hepatoerythropoietic Porphyria HEP Uroporphyrinogen Decarboxylase Deficiency Pct Pct, Type Ii Porphyria, Hepatocutaneous Type Urod Deficiency Porphyria, Hepatoerythropoietic Porphyria Cutanea Tarda, Susceptibility To Familial Porphyria Cutanea Tarda Porphyria Cutanea Tarda, Type Ii Pct, 'Familial' Type Porphyria, Hepatic FPCT Pct Type Ii Porphyria Cutanea Tarda Type Ii Porphyria Hepatocutaneous Type Heterozygous Uroporphyrinogen Decarboxylase Deficiency Urod - [Uroporphyrinogen Decarboxylase] Deficiency Pct - [Porphyria Cutanea Tarda]
Mirage Syndrome	Myelodysplasia, Infection, Restriction Of Growth, Adrenal Hypoplasia, Genital Phenotypes, And Enteropathy MIRAGE Myelodysplasia, Infection, Restriction Of Growth, Adrenal Hypoplasia, Genital Phenotypes, Enteropathy Myelodysplasia-Infection-Restriction Of Growth-Adrenal Hypoplasia-Genital Anomalies-Enteropathy Syndrome Myelodysplasia-Infection-Restriction Of Growth-Adrenal Hypoplasia-Genital Phenotypes-Enteropathy Syndrome Bone Marrow Diseases
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Ureteral Obstruction
Nutritional Deficiency Disease	Malnutrition Nutritional Disorder Nutritional Deficiency Nutrition Deficiency Diseases Carbamoyl-Phosphate Synthase I Deficiency Disease Nutrition Disorders
Hemosiderosis	Haemosiderosis Iron Overload
Poems Syndrome	Crow-Fukase Syndrome Osteosclerotic Myeloma Polyneuropathy Organomegaly Polyneuropathy, Organomegaly, Endocrinopathy, M Protein, And Skin Changes Syndrome Pep Syndrome Polyneuropathy-Endocrinopathy-Plasma Cell Dyscrasia Syndrome Takatsuki Syndrome
Neutropenia	Leukopenia
Folic Acid Deficiency Anemia	Folate Deficiency Anaemia Folic Acid Deficiency Anaemia Folate Deficiency Anemia Folate-Deficiency Anaemia Folate-Deficiency Anemia Folate-Deficient Megaloblastic Anaemia Megaloblastic Anemia Due To Folate Deficiency Anaemia Of Folate Deficiency Folate Or Folic Acid Deficiency Anaemia Nos Folic Acid Deficiency Anaemia Nos Acquired Megaloblastic Anaemia Due To Nutritional Folate Deficiency Dietary Folic Acid Deficiency Anaemia Dietary Folate Deficiency Anaemia Folate Deficiency Anaemia Due To Dietary Causes Goat'S Milk Anaemia Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Increased Requirement Megaloblastic Anaemia Due To Increased Requirements Of Folate Acquired Megaloblastic Anaemia Due To Folate Deficiency Secondary To Intestinal Disorders Acquired Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate Megaloblastic Anaemia Due To Decreased Intestinal Absorption Of Folate
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Sickle Cell Disease	Hbs Disease Hemoglobin S Disease Scd Sickle Cell Disorders Sickling Disorder Due To Hemoglobin S Anemia, Sickle Cell Hb-Ss Disease Without Crisis Hbss Without Crisis Sickle-Cell Anaemia Without Crisis Scd - [Sickle Cell Disease] Sca - [Sickle Cell Anaemia] Sickle Cell Disease Nos Sickle Cell Disorder Sickle Cell Syndrome Sickle-Cell Anaemia Nos Sickle-Cell Disorder Nos Haemoglobin S Disease Haemoglobin Ss Disease Hb S Disease Hb Ss Disease Herrick Anaemia Hereditary Haemoglobinopathy Disorder Homozygous For Haemoglobin S Sickle-Cell Haemoglobin Disease Sickling Disorder Due To Haemoglobin S Hb-Ss Disease With Crisis Sickle Cell Crisis Sickle-Cell Disorder With Crisis Sickle-Cell Anaemia With Crisis Hbss With Crisis Hb S Disease With Mention Of Crisis Haemoglobin Ss Disease With Crisis Hb-Ss Disease With Vaso-Occlusive Pain Vaso-Occlusive Crisis
Microcytic Anemia	Iron-Refractory Iron Deficiency Anemia
Hemoglobinopathy	Hemoglobinopathies
Stress Polycythemia	Gaisbock'S Syndrome Polycythemia, Emotional Pseudopolycythaemia Gaisboeck'S Syndrome Pseudopolycythemia Gaisbock Syndrome Stress Erythrocytosis Pseudo-Polycythemia Relative Erythrocytosis
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Ovarian Clear Cell Cystadenocarcinoma
Fallopian Tube Mucinous Adenocarcinoma
Mixed Epithelial Tumor Of Ovary	Ovarian Mixed Epithelial Tumor Mixed Epithelial Tumour Of Ovary Ovarian Mixed Epithelial Tumour
Ovarian Clear Cell Malignant Adenofibroma	Ovarian Clear Cell Adenocarcinofibroma
Fallopian Tube Transitional Cell Carcinoma
Splenomegaly
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Transient Erythroblastopenia Of Childhood	Erythroblastopenia, Transient Transient Acquired Pure Red Cell Aplasia TEC Familial Transient Erythroblastopenia Of Childhood
Hemoglobinuria
Sleep Apnea	Sleep Apnea Syndromes
Erythrocytosis, Familial, 2	Chuvash Polycythemia ECYT2 Familial Erythrocytosis 2 Autosomal Recessive Benign Erythrocytosis Polycythemia, Vhl-Dependent Chuvash Erythromatosis Chuvash Type Polycythemia Chuvash Erythrocytosis Von Hippel-Lindau-Dependent Polycythemia Polycythemia Chuvash Type Vhl-Dependent Polycythemia Erythrocytosis, Familial, Type 2
Thrombosis	Thrombosis Of Blood Vessel
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Asphyxia Neonatorum	Birth Asphyxia Postnatal Asphyxia Asphyxia - Birth Asphyxia, In Liveborn Infant Hypoxia Neonatorum Hypoxia, In Liveborn Infant Intrapartum Asphyxia Neonatal Asphyxia Newborn Asphyxia Asphyxia In Liveborn Infant Asphyxia Of Newborn Nos Perinatal Asphyxia Perinatal Hypoxia Newborn Asphyxiation
Porphyria	Hematoporphyria Porphyrias Disorder Of Porphyrin And Hem Metabolism Disorder Of Porphyrin Metabolism Porphyrinopathy Porphyrin Disorder Disorder Of Porphyrin And Heme Metabolism Disorders Of Porphyrin Metabolism
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Erythrocytosis, Familial, 1	ECYT1 Pfcp Primary Familial And Congenital Polycythemia Familial Erythrocytosis 1 Familial Erythrocytosis Polycythemia, Primary Familial And Congenital Autosomal Dominant Benign Erythrocytosis Familial Erythrocytosis Type 1 Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation Congenital Polycythemia Due To Erythropoietin Receptor Mutation Primary Congenital Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Autosomal Dominant Benign Erythrocytosis, Somatic Autosomal Dominant Familial Erythrocytosis-1 Erythrocytosis Autosomal Dominant Benign Familial Primary Polycythemia Familial Erythrocytosis, 1 Erythrocytosis, Familial, Type 1
Pulmonary Edema
Acquired Immunodeficiency Syndrome	Acquired Immune Deficiency Syndrome AIDS Acquired Immune Deficiency Acquired Immunodeficiency Acquired Immunodeficiency Due To Protein Loss
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Diabetes Mellitus	Diabetes
Neuropathy	Peripheral Neuropathy Peripheral Neuropathies
Erythema Infectiosum	Fifth Disease Slapped Cheek Syndrome Parvovirus B19 Infection
Pure Autonomic Failure	Orthostatic Hypotension Idiopathic Orthostatic Hypotension Postural Hypotension Bradbury-Eggleston Syndrome Bradbury Eggleston Syndrome Hypotension, Orthostatic Hypotension, Postural Paf Pure Dysautonomia Pure Idiopatic Dysautonomia Hypotension Orthostatic Primary Orthostatic Hypotension Chronic Orthostatic Hypotension
Analbuminemia	ANALBA Congenital Analbuminemia Hypoalbuminemia
Anemia, Congenital Dyserythropoietic, Type Ia	Congenital Dyserythropoietic Anemia Type I Cda I CDAN1A Congenital Dyserythropoietic Anemia Type 1 Congenital Dyserythropoietic Anemia Type Ia Congenital Dyserythropoietic Anemia, Type I Anemia, Congenital Dyserythropoietic, Type I Cda Type 1 Cda Type I Cda Ia Dyserythropoietic Anemia, Congenital Type 1 Anemia, Congenital Dyserythropoietic, Type 1a Dyserythropoietic Anemia, Congenital, Type Ia Cda, Type Ia Congenital Dyserythropoietic Anaemia Type 1 Congenital Dyserythropoietic Anaemia Type I Anemia, Dyserythropoietic, Congenital Type 1 Type I Congenital Dyserythropoietic Anemia Anemia, Congenital Dyserythropoietic, 1a Anemia, Dyserythropoietic, Congenital, Type Ia
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Renal Fibrosis
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Plethora Of Newborn	Neonatal Polycythemia
Retinal Detachment	Retinal Detachments Rhegmatogenous Retinal Detachment Ruptured Retina With Detachment Retinal Hole With Detachment
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Acute Erythroid Leukemia	Acute Erythroleukemia Di Guglielmo'S Syndrome Aml M6 Acute Myeloid Leukemia Fab-M6 Acute Myeloid Leukemia M6 Erythroleukemia Aml-M6 Acute Erythroleukemia M6a Subtype Acute Erythroleukemia M6b Subtype Di Guglielmo Syndrome Acute Myeloid Leukemia, M6 Type Acute Erythroblastic Leukemia Acute Erythroleukemia - M6a Subtype Acute Erythroleukemia - M6b Subtype Acute Erythraemia And Erythroleukaemia Acute Erythroid Leukaemia Without Mention Of Remission Erythraemia Erythraemic Myelosis Erythroleukaemia Acute Erythraemic Myelosis Acute Erythraemia
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome
Myelophthisic Anemia	Myelophthisis Anemia Leukoerythroblastic Anemia, Leukoerythroblastic Leukoerythroblastosis Anemia, Myelophthisic Leukoerythroblastic Anemia
Beta-Thalassemia Intermedia
Anemia, Sideroblastic, 1	Xlsa X-Linked Sideroblastic Anemia Hypochromic Anemia Anh1 Hereditary Iron-Loading Anemia Anemia, Sideroblastic, X-Linked Anemia, Hereditary Sideroblastic Erythroid 5-Aminolevulinate Synthase Deficiency Hereditary Sideroblastic Anemia SIDBA1 Anemia, Hypochromic Sideroblastic Anemia 1 Anemia Hypochromic X Chromosome-Linked Sideroblastic Anemia Sideroblastic Anaemia 1 X-Linked Sideroblastic Anaemia Anemia Hereditary Sideroblastic Anemia Sex-Linked Hypochromic Sideroblastic Congenital Sideroblastic Anemia Sideroblastic Anemia X-Linked Anemia, Sex-Linked Hypochromic Sideroblastic Congenital Sideroblastic Anaemia X-Linked Pyridoxine-Responsive Sideroblastic Anemia Anemia Congenital Sideroblastic Anemia, Sideroblastic, Type 1 Sex-Linked Hypochromic Sideroblastic Anaemia Autosomal Recessive Sideroblastic Anaemia Familial Sex Linked Hypochromic Anaemia
Progressive Myoclonus Epilepsy 9	Emp9 Pme Type 9 Progressive Myoclonic Epilepsy Due To Lmnb2 Deficiency Progressive Myoclonus Epilepsy Type 9
Viral Exanthem	Viral Rash Nos Virus Exanthema Nonspecific Exanthematous Viral Infection Nonspecific Viral Exanthem Nonspecific Viral Rash Viral Enanthema Nos Viral Disease Characterised By Exanthem Viral Exanthemata Viral Exanthem, Unspecified Viral Exanthema Nos
Encephalomalacia
Splenic Sequestration
Periventricular Leukomalacia	Leukomalacia, Periventricular Pvl Leukomalacia Periventricular
Beta-Thalassemia Major	Cooley'S Anemia Cooley Anemia Mediterranean Anemia
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Hemochromatosis, Type 1	Hemochromatosis Hemochromatosis Type 1 Hereditary Hemochromatosis Hh HFE1 Hfe Hemochromatosis, Modifier Of Symptomatic Form Of Classic Hemochromatosis Symptomatic Form Of Hemochromatosis Type 1 Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis Haemochromatosis Iron Storage Disorder Bronze Diabetes Hereditary Haemochromatosis Hlah Hfe Hemochromatosis, Hereditary Diabetes Bronze Classic Hemochromatosis Hfe-Associated Hereditary Hemochromatosis Hemochromatosis Classic Bronzed Cirrhosis Familial Hemochromatosis Genetic Hemochromatosis Hc Pigmentary Cirrhosis Primary Hemochromatosis Troisier-Hanot-Chauffard Syndrome Von Recklenhausen-Applebaum Disease Hemochromatosis 1 Primary Hereditary Hemochromatosis Bronze Cirrhosis
Type 1 Diabetes Mellitus 19	Diabetes Mellitus, Insulin-Dependent, 19 IDDM19 T1D19 Insulin-Dependent Diabetes Mellitus 19
Parathyroid Gland Disease	Parathyroid Diseases Disease Of Parathyroid Glands Parathyroid Disease
Blood Group Incompatibility
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Hypochromic Microcytic Anemia	Anemia, Hypochromic Microcytic Microcytic Hypochromic Anemia
Vitamin B12 Deficiency	Cobalamin Deficiency Hypocobalaminemia Vitamin B 12 Deficiency Cyanocobalamin Deficiency Deficiency Of Vitamin B12
Uremic Neuropathy
Thalassemia Minor
Vitamin Metabolic Disorder
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Congenital Hemolytic Anemia	Anemia Hemolytic Congenital Anemia, Hemolytic, Congenital Congenital Hemolytic Anaemia Hereditary Hemolytic Anaemia Hereditary Hemolytic Anemia
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Retinal Degeneration	Degeneration Of Retina
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Renal Artery Disease	Renal Vascular Disease Vascular Disorder Of Kidney Renal Vascular Disorder
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Chronic Pyelonephritis
Renal Hypertension	Hypertension Renal Hypertension, Renal
Epiglottis Cancer	Epiglottic Cancer Malignant Tumor Of Epiglottis
Neovascular Glaucoma	Glaucoma, Neovascular Secondary Angle-Closure Glaucoma With Rubeosis Glaucoma Neovascular
Retinal Ischemia
Kidney Fibrosarcoma	Fibrosarcoma Of The Kidney
Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement	Myeloid/Lymphoid Neoplasm Associated With Pdgfra Rearrangement Myeloid And Lymphoid Neoplasms With Pdgfra Rearrangement
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Blood Protein Disease	Blood Protein Disorders Blood Protein Disorder
Carotid Artery Occlusion	Occlusion And Stenosis Of Carotid Artery
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Perinatal Necrotizing Enterocolitis	Necrotizing Enterocolitis Enterocolitis Necrotizing Enterocolitis, Necrotizing Necrotizing Enterocolitis In Fetus Or Newborn Perinatal Necrotising Enterocolitis Pseudomembranous Enterocolitis In Newborn Nec
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Metal Metabolism Disorder	Metal Metabolism, Inborn Errors Inborn Metal Metabolism Disorder
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Erythrocytosis, Familial, 6	ECYT6 Erythrocytosis 6 Familial Erythrocytosis 6 Erythrocytosis, Beta-Globin Type Polycythemia, Beta-Globin Type Beta-Globin Type Erythrocytosis Beta-Globin Type Polycythemia
Anemia, Autoimmune Hemolytic	Autoimmune Hemolytic Anemia Idiopathic Autoimmune Hemolytic Anemia Immuno-Hemolytic Anemia Anemia, Hemolytic, Autoimmune Autoimmune Haemolytic Anaemia Autoimmune Hemolytic Anaemia Acquired Autoimmune Hemolytic Anemia Anemia Hemolytic Autoimmune Familial Auto-Immune Hemolytic Anemia Aha Aiha
Peripheral Vascular Disease	Peripheral Arterial Disease Arterial Occlusive Disease Arterial Occlusive Diseases Pad Peripheral Vascular Diseases Peripheral Occlusive Disease Peripheral Arterial Diseases Helicobacter Infections
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Conidiobolomycosis	Infection By Conidiobolus Rhinoentomophthoromycosis Entomophthoromycosis Conidiobolae
Esophagus Carcinoma In Situ	Carcinoma In Situ Of Esophagus Carcinoma In Situ Of Oesophagus Oesophagus Carcinoma In Situ Severe Esophageal Dysplasia Stage 0 Carcinoma Of The Esophagus Stage 0 Carcinoma Of The Oesophagus Severe Oesophageal Dysplasia
Tremor, Hereditary Essential, 2	ETM2 Essential Tremor 2 Essential Tremor, Hereditary, 2 Hereditary Essential Tremor 2 Tremor Hereditary Essential, 2
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Ceftazidime Allergy	Fortaz Allergy Tazicef Allergy
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Fallopian Tube Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Fallopian Tube
Patent Ductus Arteriosus 1	Patent Ductus Arteriosus PDA1 Pda Ductus Arteriosus, Patent Patent Ductus Arteriosus, Susceptibility To Patent Ductus Botalli Patency Of The Ductus Arteriosus Patent Ductus Arteriosus Familial Ductus Arteriosus Patent Patent Ductus Arteriosus - Persisting Type
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Intracranial Berry Aneurysm	Familial Aneurysmal Subarachnoid Hemorrhage Familial Berry Aneurysm Familial Intracranial Saccular Aneurysm Saccular Cerebral Aneurysm Aneurysm, Intracranial Berry Aneurysmal Subarachnoid Hemorrhage Aneurysm, Intracranial Berry, 1
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12654	Molidustat	Inhibitor	99.70%	Phase 3
HY-17029	Epothilone B		99.91%	Phase 3
HY-P0168	Cibinetide	Agonist	99.86%	Phase 2
HY-163839	DS-1093a	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145405	C12-200		99.91%	Unkown
HY-112144	TP0463518	Inhibitor	99.25%	Unkown
HY-13503	Epothilone A		99.81%	Unkown
HY-W040203	Decyl β-D-maltopyranoside		99.94%	Unkown
HY-112624K	Dextran T5 (MW 5,000)		/	Unkown
HY-W062700	STS-E412	Activator	99.72%	Unkown
HY-141625	TRC160334	Inhibitor	98.22%	Unkown
HY-141625A	TRC160334 sodium	Inhibitor	/	Unkown
HY-155009	PHD2-IN-1	Inhibitor	/	Unkown
HY-156526	PHD-IN-1	Inhibitor	/	Unkown
HY-161660	DS44470011	Inhibitor	/	Unkown
HY-162438	PHD2-IN-2	Inhibitor	/	Unkown
HY-177271	PHD2-IN-6	Inhibitor	/	Unkown
HY-179647	ZG-2686	Agonist	/	Unkown
HY-183583	HIF-2α-IN-18	Inhibitor	/	Unkown
HY-P0168A	Cibinetide acetate	Agonist	/	Unkown
HY-RS04446	EPO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04459	EPX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14538	TIMP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W747868	Molidustat sodium	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-172335	C9-200		/	Unkown
HY-174495	Human EPO mRNA		/	Unkown
HY-RS16566	Epo Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22999	Epo Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991881	KY1070		/	Unkown
HY-108864	Epoetin alfa	Agonist	/	Unkown
HY-P991976	Anti-EPO Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EPO	VGNC	VGNC:28549
Mus musculus	EPO	MGD	MGI:95407
Felis catus	EPO	VGNC	VGNC:61915
Rattus norvegicus	EPO	RGD	RGD:2559
Macaca mulatta	EPO	VGNC	VGNC:72246
Canis familiaris	EPO	VGNC	VGNC:40422
Others	EPO	NCBI