Epoetin alfa
Epoetin alfa (Epogen) is a recombinant human erythropoietin whose amino acid sequence and biological activity are identical to those of endogenous erythropoietin (EPO). Epoetin alfa is a direct agonist of the EPO receptor (EPOR) on the surface of erythroid progenitor cells, and promotes the production and maturation of red blood cells. Epoetin alfa can be used for research on myelodysplastic syndrome-related anemia and hematological malignancies.
For research use only. We do not sell to patients.
- CAS No.: 113427-24-0
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Epoetin alfa is produced via recombinant DNA technology in mammalian cells (CHO cells). By binding to EPOR and activating downstream signaling pathways, it stimulates the bone marrow to produce red blood cells[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Product Image
Chemical Information
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CAS No. 113427-24-0
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SMILES
[Epoetin alfa]
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Synonyms
Epogen
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1].
Gascón P, et al. Epoetin alfa for the treatment of myelodysplastic syndrome-related anemia: A review of clinical data, clinical guidelines, and treatment protocols. Leuk Res. 2019 Jun;81:35-42.
[Content Brief]
[2].
Straus DJ. Epoetin alfa therapy for patients with hematologic malignancies and mild anemia. Clin Lymphoma. 2003 Aug;4 Suppl 1:S13-7.
[Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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