PHD-IN-1
PHD-IN-1 (compound 80) is a potent inhibitor of PHD2，with an IC50 value of ≤5 nM. PHD-IN-1 shows EC50s of 2.5 μM in EPO Elisa assay both in Caco2-HIFla-HiBiT-clone-1 cells and Hep3B cells，respectively.
For research use only. We do not sell to patients.
- CAS No.: 2924182-31-8
- Formula: C24H23N7O2
- Molecular Weight:441.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: ≤5 nM (PHD2)[1]
Chemical Information
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CAS No. 2924182-31-8
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Molecular Weight 441.49
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Formula C24H23N7O2
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SMILES
OC1=C(C(NCC2=CN=C(C#N)C=C2)=O)N=CC3=C1C=CC(N4[C@]5([H])CN(C6CC6)[C@](C5)([H])C4)=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Enzyme-Linked Immunosorbent Assay (ELISA)
Enzyme-linked immunosorbent assay (ELISA) is a biochemical technology widely used to detect and quantify proteins, antibodies, hormones and other biomolecules. This method uses enzyme-labeled antibodies or antigens to specifically bind to the test substance, and generates a measurable signal through an enzyme-catalyzed reaction. ELISA has the characteristics of high sensitivity, specificity and high-throughput, and is suitable for medical diagnosis, biomedical research and drug development and other fields.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PHD-IN-1 Related Classifications
HY-156526 Related Classifications
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