Snapin - SNAP-associated protein Gene

Mus musculus

Also known as 25kDa; Snapap; Bloc1s7; Snap25bp

Gene ID: 20615 | Gene type: protein coding

About Snapin

Summary

Predicted to enable SNARE binding activity. Involved in anterograde synaptic vesicle transport; negative regulation of neuron projection development; and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including lysosomal lumen acidification; terminal button organization; and vesicle organization. Located in acrosomal vesicle; cytosol; and manchette. Part of BLOC-1 complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human SNAPIN (SNAP associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Snapin Products(1)

mRNA	Protein	Name
NM_133854.3	NP_598615.1	SNARE-associated protein Snapin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15102850	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterograde axonal transport	IMP IMP: Inferred from mutant phenotype	21998198	MGI
involved in anterograde synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	21998198	MGI
acts upstream of or within autophagosome maturation	IMP IMP: Inferred from mutant phenotype	20920792	MGI
acts upstream of or within chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	19217378	MGI
acts upstream of or within establishment of vesicle localization	IMP IMP: Inferred from mutant phenotype	20920792	MGI
acts upstream of or within late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	20920792	MGI
acts upstream of or within lysosomal lumen acidification	IMP IMP: Inferred from mutant phenotype	20920792	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	20920792	MGI
involved in negative regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	21986494	MGI
acts upstream of or within neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	20920792	MGI
acts upstream of or within protein maturation	IMP IMP: Inferred from mutant phenotype	20920792	MGI
acts upstream of or within protein-containing complex localization	IMP IMP: Inferred from mutant phenotype	20920792	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	19217378	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	19217378	MGI
acts upstream of or within retrograde axonal transport	IMP IMP: Inferred from mutant phenotype	20920792	MGI
acts upstream of or within synaptic vesicle fusion to presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	19217378	MGI
acts upstream of or within synaptic vesicle maturation	IMP IMP: Inferred from mutant phenotype	19217378	MGI
acts upstream of or within terminal button organization	IMP IMP: Inferred from mutant phenotype	19217378	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of BLOC-1 complex	IDA IDA: Inferred from direct assay	15102850	MGI
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	31146259	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	31146259	MGI
located in cytosol	IDA IDA: Inferred from direct assay	15102850	MGI
located in manchette	IDA IDA: Inferred from direct assay	31146259	MGI
is active in microvesicle	IDA IDA: Inferred from direct assay	16760431	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SNARE-associated protein Snapin

BLOC-1 subunit 7	biogenesis of lysosome-related organelles complex 1 subunit 7
synaptosomal-associated protein 25 binding protein	synaptosomal-associated protein, 25 kDa, binding protein

Snapin Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Snapin	Q9Z266	Csnk1d	Rattus norvegicus	Q06486-2	Y2H Array	17101137
Cross	Snapin	Q9Z266	Csnk1d	Rattus norvegicus	Q06486-2	Anti Tag CoIP	17101137

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13481	SNAPIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Snapin	NCBI	NCBI:23557

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