Sox15 - SRY (sex determining region Y)-box 15 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20670

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of satellite cell activation involved in skeletal muscle regeneration; and trophoblast giant cell differentiation. Acts upstream of or within several processes, including myoblast development; negative regulation of striated muscle tissue development; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and thymus. Orthologous to human SOX15 (SRY-box transcription factor 15). [provided by Alliance of Genome Resources, Apr 2022]

Sox15 Products (1)

mRNA	Protein	Name
NM_009235.2	NP_033261.1	protein SOX-15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10821863	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	22344693	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	15863505	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15863505	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15863505	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell differentiation	IGI IGI: Inferred from genetic interaction	16759287	MGI
acts upstream of or within myoblast development	IMP IMP: Inferred from mutant phenotype	15367664	MGI
acts upstream of or within negative regulation of striated muscle tissue development	IDA IDA: Inferred from direct assay	10821863	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10821863	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17363903	MGI
involved in positive regulation of G0 to G1 transition	IMP IMP: Inferred from mutant phenotype	17363903	MGI
involved in positive regulation of myoblast proliferation	IMP IMP: Inferred from mutant phenotype	17363903	MGI
involved in positive regulation of satellite cell activation involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	17363903	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16759287	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15863505	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17363903	MGI
acts upstream of or within skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	15367664	MGI
involved in trophoblast giant cell differentiation	IMP IMP: Inferred from mutant phenotype	16759287	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12915303	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10821863	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	22344693	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein SOX-15	SRY-box containing gene 15

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13588	SOX15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22815	Sox15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29330	Sox15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox15	NCBI	NCBI:6665