Sparc - secreted acidic cysteine rich glycoprotein Gene

Also Known as ON; BM-40

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20692

Summary

Enables calcium ion binding activity and extracellular matrix binding activity. Acts upstream of or within several processes, including bone development; cellular response to growth factor stimulus; and pigmentation. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Apr 2022]

Sparc Products (2)

mRNA Protein Name
NM_001290817.1 NP_001277746.1 SPARC isoform 2 precursor
NM_009242.5 NP_033268.1 SPARC precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
3427055 MGI
enables extracellular matrix binding IDA
IDA: Inferred from direct assay
18757743 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21182835 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
22876197 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
7848824 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
25340873 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
17299058 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
8906420 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
3427055 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SPARC

  • basement-membrane protein 40

  • osteonectin

  • secreted protein acidic and rich in cysteine

Recombinant Sparc Proteins

Cat. No. Product Name Accession Purity
HY-P71086 SPARC Protein, Mouse (HEK293, His) P07214 (A18-I302) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13631 SPARC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10335 SPARC (119-122) (mouse) / Unkown
HY-RS16848 Sparc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23289 Sparc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sparc NCBI NCBI:6678