Wdr11 - WD repeat domain 11 Gene

Also Known as Brwd2; mKIAA1351; 2900055P10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 207425

Summary

Involved in several processes, including cilium assembly; heart development; and regulation of smoothened signaling pathway. Located in axoneme; ciliary basal body; and nucleus. Is expressed in several structures, including central nervous system; frontal bone primordium; metanephros; otic capsule; and submandibular gland primordium. Used to study Kallmann syndrome and ciliopathy. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 14 with or without anosmia. Orthologous to human WDR11 (WD repeat domain 11). [provided by Alliance of Genome Resources, Apr 2022]

Wdr11 Products (1)

mRNA Protein Name
NM_172255.3 NP_758459.2 WD repeat-containing protein 11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29263200 MGI
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IDA
IDA: Inferred from direct assay
29263200 MGI
involved in head development IMP
IMP: Inferred from mutant phenotype
29263200 MGI
involved in heart development IMP
IMP: Inferred from mutant phenotype
29263200 MGI
involved in multicellular organism growth IMP
IMP: Inferred from mutant phenotype
29263200 MGI
involved in regulation of smoothened signaling pathway IDA
IDA: Inferred from direct assay
29263200 MGI
Cellular Component GO Annotation Evidence References Source
located in axoneme IDA
IDA: Inferred from direct assay
29263200 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
29263200 MGI
located in cilium IDA
IDA: Inferred from direct assay
22326026 MGI
located in nucleus IDA
IDA: Inferred from direct assay
29263200 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

WD repeat-containing protein 11

  • bromodomain and WD repeat domain containing 2

  • bromodomain and WD repeat-containing protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10436 PHIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15761 WDR11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21408 Phip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wdr11 NCBI NCBI:55717