WDR11 - WD repeat domain 11 Gene

Also Known as DR11; HH14; SRI1; BRWD2; WDR15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55717

About WDR11

Cytogenetic location: 10q26.12 Genomic coordinates (GRCh38): 10:120,851,362-120,909,524 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues and is associated with 6 phenotypes. Ubiquitous expression in thyroid (RPKM 17.7), appendix (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of Other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

WDR11 Products (1)

mRNA	Protein	Name
NM_018117.12	NP_060587.8	WD repeat-containing protein 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20887964	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	29426865	GOA
involved in vesicle tethering to Golgi	IDA IDA: Inferred from direct assay	29426865	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	29263200	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20887964	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	29426865	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29263200	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	29426865	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR11 Protein Structure

WD40

0
200
400
600
800
1000
1224 a.a.

Protein Preferred Names	Protein Names
WD repeat-containing protein 11	WD repeat domain 15

WDR11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WDR11	Q9BZH6	EMX1	Homo sapiens	Q04741	Anti Tag CoIP	29263200
Intra	WDR11	Q9BZH6	P10071-PRO_0000406137	Homo sapiens	P10071-PRO_0000406137	Anti Tag CoIP	29263200

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypogonadotropic Hypogonadism 14 With Or Without Anosmia	HH14 Hypogonadism, Hypogonadotropic, Type 14 With/Without Anosmia
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Normosmic Congenital Hypogonadotropic Hypogonadism	Normosmic Idiopathic Hypogonadotropic Hypogonadism Nihh
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Hypogonadotropic Hypogonadism 7 With Or Without Anosmia	Idiopathic Hypogonadotropic Hypogonadism HH7 Hypogonadism, Isolated Hypogonadotropic Ihh Hypogonadism, Isolated, Hypogonadotropic Hypogonadotropic Hypogonadism Isolated Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism 7 Without Anosmia Congenital Hypogonadotropic Hypogonadism Normosmic Hh Klinefelter Syndrome Isolated Gonadotropin Deficiency
Pituitary Stalk Interruption Syndrome	Ectopic Neurohypophysis Psis
Hypogonadotropic Hypogonadism	Klinefelter Syndrome Klinefelter'S Syndrome Xxy Syndrome Xxy Trisomy Hypogonadotropism 47, Xxy Congenital Idiopathic Hypogonadotropic Hypogonadism Isolated Congenital Gonadotropin Deficiency 47,Xxy Syndrome 47, Xxy Syndrome Klinefelters Syndrome Hypogonadism Klinefelter Syndrome In Males Klinefelter Syndrome, Unspecified Klinefelter Syndrome Karyotype 47, Xxy
Type 1 Diabetes Mellitus 15	Diabetes Mellitus, Insulin-Dependent, 15 Iddm15 Insulin-Dependent Diabetes Mellitus 15 T1D15 Insulin-Dependent Diabetes Mellitus-15
Alopecia Universalis Congenita	Alopecia Universalis ALUNC Atrichia, Generalized Au Alopecia Areata Universalis Atrichia Generalized
Submandibular Adenitis	Submandibular Lymphadenitis
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Paraphimosis
Robinow Syndrome, Autosomal Dominant 1	Autosomal Dominant Robinow Syndrome 1 DRS1 Robinow Dwarfism Fetal Face Syndrome Acral Dysostosis With Facial And Genital Abnormalities Robinow, Autosomal Dominant Syndrome, Type 1
Corneal Dystrophy, Band-Shaped	Band Keratopathy Band-Shaped Keratopathy
Cystic Echinococcosis	Echinococcus Granulosus Infection Echinococcus Granulosus Infection Of Lung Echinococcus Granulosus Echinococcus Granulosus Infection Of Thyroid Echinococcus Granulosus Infectious Disease Echinococcus Granulosus Infectious Disease Of Liver Echinococcus Granulosus Infectious Disease Of Thyroid Liver Echinococcus Granulosus Lung Echinococcus Granulosus Thyroid Echinococcus Granulosus Unilocular Echinococcosis Unilocular Hydatid Disease Hydatid Disease Hydatidosis Echinococcosis
Limited Scleroderma	Limited Cutaneous Systemic Sclerosis Limited Systemic Sclerosis Systemic Sclerosis Sine Scleroderma Crest Syndrome Limited Cutaneous Systemic Scleroderma Scleroderma, Limited Systemic Sclerosis, Limited Progressive Systemic Sclerosis Sine Scleroderma Scleroderma, Sine Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10436	PHIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15761	WDR11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21408	Phip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WDR11	MGD	MGI:1920230
Felis catus	WDR11	VGNC	VGNC:67014
Canis familiaris	WDR11	VGNC	VGNC:48350
Rattus norvegicus	WDR11	RGD	RGD:1587347
Bos taurus	WDR11	VGNC	VGNC:36881
Macaca mulatta	WDR11	VGNC	VGNC:78936
Others	WDR11	NCBI