Sptlc2 - serine palmitoyltransferase, long chain base subunit 2 Gene

Also Known as LCB2; Spt2; LCB2a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20773

Summary

This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. A mutant allele of this gene in mice is used as a model for the human disease 'Susceptibilty to Psoriasis 1'. Mutations in the human gene are associated with hereditary sensory neuropathy type I. [provided by RefSeq, Sep 2015]

Sptlc2 Products (1)

mRNA Protein Name
NM_011479.4 NP_035609.1 serine palmitoyltransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
contributes to serine C-palmitoyltransferase activity IDA
IDA: Inferred from direct assay
9363775 MGI
Biological Process GO Annotation Evidence References Source
involved in adipose tissue development IMP
IMP: Inferred from mutant phenotype
27818258 MGI
acts upstream of or within ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
16216550 MGI
acts upstream of or within sphinganine biosynthetic process IDA
IDA: Inferred from direct assay
9363775 MGI
involved in sphingolipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
28698261 MGI
acts upstream of or within sphingomyelin biosynthetic process IMP
IMP: Inferred from mutant phenotype
16216550 MGI
acts upstream of or within sphingosine biosynthetic process IMP
IMP: Inferred from mutant phenotype
16216550 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine palmitoyltransferase 2

  • LCB 2

  • SPT 2

  • long chain base biosynthesis protein 2

  • long chain base biosynthesis protein 2a

  • serine-palmitoyl-CoA transferase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13737 SPTLC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sptlc2 NCBI NCBI:9517