Sptlc2 - serine palmitoyltransferase, long chain base subunit 2 Gene

Mus musculus

Also known as LCB2; Spt2; LCB2a

Gene ID: 20773 | Gene type: protein coding

About Sptlc2

Summary

This gene encodes a long chain base subunit of serine palmitoyltransferase. The enzyme, serine palmitoyltransferase, consists of two different subunits, and is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. A mutant allele of this gene in mice is used as a model for the human disease 'Susceptibilty to Psoriasis 1'. Mutations in the human gene are associated with hereditary sensory neuropathy type I. [provided by RefSeq, Sep 2015]

Sptlc2 Products(1)

mRNA	Protein	Name
NM_011479.4	NP_035609.1	serine palmitoyltransferase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to serine C-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	9363775	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	27818258	MGI
acts upstream of or within ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	16216550	MGI
acts upstream of or within sphinganine biosynthetic process	IDA IDA: Inferred from direct assay	9363775	MGI
involved in sphingolipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	28698261	MGI
acts upstream of or within sphingomyelin biosynthetic process	IMP IMP: Inferred from mutant phenotype	16216550	MGI
acts upstream of or within sphingosine biosynthetic process	IMP IMP: Inferred from mutant phenotype	16216550	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine palmitoyltransferase 2

LCB 2	SPT 2
long chain base biosynthesis protein 2	long chain base biosynthesis protein 2a
serine-palmitoyl-CoA transferase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13737	SPTLC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sptlc2	NCBI	NCBI:9517

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