Dis3l2 - DIS3 like 3'-5' exoribonuclease 2 Gene

Also Known as 4930429A22Rik; 8030493P09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 208718

Summary

Enables 3'-5'-exoribonuclease activity; magnesium ion binding activity; and poly(U) RNA binding activity. Involved in miRNA catabolic process and stem cell population maintenance. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; ganglia; metanephros; and nose. Used to study Perlman syndrome. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Apr 2022]

Dis3l2 Products (2)

mRNA Protein Name
NM_001172157.1 NP_001165628.1 DIS3-like exonuclease 2 isoform 1
NM_153530.2 NP_705758.1 DIS3-like exonuclease 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
23594738 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
25119025 MGI
enables poly(U) RNA binding IDA
IDA: Inferred from direct assay
25119025 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23594738 MGI
Biological Process GO Annotation Evidence References Source
involved in miRNA catabolic process IDA
IDA: Inferred from direct assay
25119025 MGI
involved in miRNA catabolic process IMP
IMP: Inferred from mutant phenotype
23594738 MGI
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
23594738 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23594738 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DIS3-like exonuclease 2

  • DIS3 mitotic control homolog-like 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03780 DIS3L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-173081 4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dis3l2 NCBI NCBI:129563