Ulk4 - unc-51-like kinase 4 Gene

Mus musculus

Also known as A730098P15; 4932415A06Rik

Gene ID: 209012 | Gene type: protein coding

About Ulk4

Summary

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within several processes, including cerebrospinal fluid circulation; cilium organization; and nervous system development. Is expressed in brain. Used to study hydrocephalus. Orthologous to human ULK4 (unc-51 like kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Ulk4 Products(1)

mRNA	Protein	Name
NM_177589.3	NP_808257.2	serine/threonine-protein kinase ULK4

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within GABAergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	29391390	MGI
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	29391390	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within axoneme assembly	IMP IMP: Inferred from mutant phenotype	27445138	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	27445138	MGI
acts upstream of or within central nervous system myelination	IMP IMP: Inferred from mutant phenotype	29034508	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	34235142	MGI
acts upstream of or within cerebrospinal fluid circulation	IMP IMP: Inferred from mutant phenotype	27445138	MGI
acts upstream of or within ciliary basal body organization	IMP IMP: Inferred from mutant phenotype	27445138	MGI
acts upstream of or within cognition	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within corpus callosum development	IMP IMP: Inferred from mutant phenotype	24284070	MGI
acts upstream of or within dendritic spine development	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement	IMP IMP: Inferred from mutant phenotype	21746835	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	21746835	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	29034508	MGI
acts upstream of or within layer formation in cerebral cortex	IMP IMP: Inferred from mutant phenotype	34235142	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within motile cilium assembly	IMP IMP: Inferred from mutant phenotype	21746835	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	27300315	MGI
acts upstream of or within neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	29034508	MGI
acts upstream of or within neuronal stem cell division	IMP IMP: Inferred from mutant phenotype	27300315	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within pyramidal neuron differentiation	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within regulation of signal transduction	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within regulation of tau-protein kinase activity	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within sensory perception	IMP IMP: Inferred from mutant phenotype	35522199	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: Inferred from direct assay	34463328	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	29391390	MGI
acts upstream of or within ventricular system development	IMP IMP: Inferred from mutant phenotype	21746835	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cilium	IDA IDA: Inferred from direct assay	34463328	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein kinase ULK4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15458	ULK4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ulk4	NCBI	NCBI:54986

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