Stx1a - syntaxin 1A (brain) Gene

Also Known as HPC-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20907

Summary

Enables SNARE binding activity and Calcium Channel Inhibitor activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of synaptic vesicle priming; and signal release. Acts upstream of or within calcium-ion regulated exocytosis. Located in several cellular components, including axon; nuclear membrane; and secretory vesicle. Is integral component of plasma membrane. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is expressed in several structures, including adrenal gland; aorta; intercostal muscle; nervous system; and retina. Used to study disease of mental health. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Apr 2022]

Stx1a Products (2)

mRNA	Protein	Name
NM_001359179.1	NP_001346108.1	syntaxin-1A isoform 2
NM_016801.4	NP_058081.2	syntaxin-1A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	12145198	MGI
enables calcium channel inhibitor activity	IMP IMP: Inferred from mutant phenotype	10468580	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7890599	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within calcium-ion regulated exocytosis	IMP IMP: Inferred from mutant phenotype	10468580	MGI
involved in hormone secretion	IMP IMP: Inferred from mutant phenotype	28596237	MGI
involved in insulin secretion	IMP IMP: Inferred from mutant phenotype	17502420	MGI
involved in positive regulation of excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	24133272	MGI
involved in positive regulation of neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	24133272	MGI
involved in regulated exocytosis	IMP IMP: Inferred from mutant phenotype	17502420	MGI
involved in regulation of synaptic vesicle priming	IGI IGI: Inferred from genetic interaction	24133272	MGI
involved in synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	27466336	MGI
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	27466336	MGI
involved in vesicle docking	IMP IMP: Inferred from mutant phenotype	17502420	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in acrosomal vesicle	EXP EXP: Inferred from Experiment	16540102	MGI
located in axon	IDA IDA: Inferred from direct assay	23821748	MGI
located in membrane	IDA IDA: Inferred from direct assay	10712642	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	15935055	MGI
located in nuclear membrane	IDA IDA: Inferred from direct assay	11092755	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10468580	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	18760330	MGI
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	12805290	MGI
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA IDA: Inferred from direct assay	15935055	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
syntaxin-1A	neuron-specific antigen HPC-1 syntaxin 1 a

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13980	STX1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stx1a	NCBI	NCBI:6804