Syt2 - synaptotagmin II Gene

Also Known as IP4BP; sytII; mKIAA4194

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20980

Summary

This gene encodes a member of the synaptotagmin protein family. Synaptotagmin proteins are involved in membrane trafficking and are characterized by an N-terminal transmembrane region as well as tandem calcium binding domains. The encoded protein is able to bind inositol polyphosphate and is thought to be involved in synaptic function and neurotransmitter release. [provided by RefSeq, Sep 2017]

Syt2 Products (2)

mRNA Protein Name
NM_001355726.1 NP_001342655.1 synaptotagmin-2
NM_009307.4 NP_033333.2 synaptotagmin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
15350218 MGI
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
7961887 MGI
enables inositol 1,3,4,5 tetrakisphosphate binding IDA
IDA: Inferred from direct assay
7961887 MGI
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
12860971 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15350218 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium-dependent activation of synaptic vesicle fusion IDA
IDA: Inferred from direct assay
17192432 MGI
involved in calcium-dependent activation of synaptic vesicle fusion IEP
IEP: Inferred from expression pattern
17192432 MGI
involved in calcium-dependent activation of synaptic vesicle fusion IMP
IMP: Inferred from mutant phenotype
17192432 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
23172916 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
17192432 MGI
is active in neuromuscular junction IEP
IEP: Inferred from expression pattern
17192432 MGI
is active in neuromuscular junction IMP
IMP: Inferred from mutant phenotype
17192432 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15350218 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-2

  • IP4-binding protein

  • inositol polyphosphate-binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14114 SYT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syt2 NCBI NCBI:127833