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Syt4 - synaptotagmin IV Gene

Also Known as SytIV

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20983

Summary

The protein encoded by this gene belongs to the synaptotagmin family. Members of this family are multi-domained, integral membrane proteins of synaptic vesicles, and are thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. This gene is primarily expressed in the nervous tissues. [provided by RefSeq, Jul 2008]

Syt4 Products (1)

mRNA	Protein	Name
NM_009308.3	NP_033334.2	synaptotagmin-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	15197251	MGI
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	8626542	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in dense core granule cytoskeletal transport	IMP IMP: Inferred from mutant phenotype	29166604	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	15390175	MGI
involved in negative regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	19448629	MGI
involved in negative regulation of retrograde trans-synaptic signaling by neuropeptide	IMP IMP: Inferred from mutant phenotype	19448629	MGI
involved in negative regulation of short-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	15390175	MGI
involved in negative regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	19448629	MGI
acts upstream of or within neurotransmitter secretion	IDA IDA: Inferred from direct assay	15197251	MGI
involved in positive regulation of dense core granule exocytosis	IMP IMP: Inferred from mutant phenotype	18468511	MGI
involved in positive regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	15197251	MGI
involved in regulation of calcium ion-dependent exocytosis	IMP IMP: Inferred from mutant phenotype	19136969	MGI
involved in regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	21576241	MGI
involved in regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	19136969	MGI
involved in regulation of postsynaptic dense core vesicle exocytosis	EXP EXP: Inferred from Experiment	19448629	MGI
involved in regulation of postsynaptic dense core vesicle exocytosis	IDA IDA: Inferred from direct assay	19448629	MGI
involved in regulation of postsynaptic dense core vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	19448629	MGI
involved in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	EXP EXP: Inferred from Experiment	19448629	MGI
involved in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	IDA IDA: Inferred from direct assay	19448629	MGI
involved in regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	19448629	MGI
involved in regulation of vesicle fusion	IMP IMP: Inferred from mutant phenotype	19136969	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12135783	MGI
located in astrocyte projection	IDA IDA: Inferred from direct assay	15197251	MGI
located in axon	IDA IDA: Inferred from direct assay	12135783	MGI
located in dendrite	IDA IDA: Inferred from direct assay	12135783	MGI
located in dense core granule	IDA IDA: Inferred from direct assay	18468511	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	19448629	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19448629	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19448629	MGI
located in microvesicle	IDA IDA: Inferred from direct assay	19136969	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	15197251	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	21576241	MGI
is active in neuronal dense core vesicle membrane	IDA IDA: Inferred from direct assay	19136969	MGI
is active in neuronal dense core vesicle membrane	IEP IEP: Inferred from expression pattern	19136969	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15197251	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12135783	MGI
located in somatodendritic compartment	IDA IDA: Inferred from direct assay	12135783	MGI
NOT located in synaptic vesicle	IDA IDA: Inferred from direct assay	12135783	MGI
located in vesicle	IDA IDA: Inferred from direct assay	12135783	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
synaptotagmin-4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14116	SYT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syt4	NCBI	NCBI:6860