Shank2 - SH3 and multiple ankyrin repeat domains 2 Gene

Also Known as ProSAP1; mKIAA1022

Species: Mus musculus

Gene Type: protein coding

Gene ID: 210274

Summary

Enables ionotropic glutamate receptor binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and synapse organization. Located in several cellular components, including neurofilament; photoreceptor inner segment; and photoreceptor outer segment. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Apr 2022]

Shank2 Products (2)

mRNA	Protein	Name
NM_001081370.3	NP_001074839.3	SH3 and multiple ankyrin repeat domains protein 2 isoform a
NM_001113373.3	NP_001106844.3	SH3 and multiple ankyrin repeat domains protein 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	15207857	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15207857	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adult behavior	IMP IMP: Inferred from mutant phenotype	22699620	MGI
involved in exploration behavior	IMP IMP: Inferred from mutant phenotype	22699620	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	22699620	MGI
involved in long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	22699620	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	22699620	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	22699620	MGI
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	22699619	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	22699620	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	22699620	MGI
involved in vocalization behavior	IMP IMP: Inferred from mutant phenotype	22699620	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	15207857	MGI
colocalizes with neurofilament	IDA IDA: Inferred from direct assay	19299912	MGI
located in neurofilament	IDA IDA: Inferred from direct assay	19299912	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	21795692	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	19299912	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	19299912	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15207857	MGI
colocalizes with postsynaptic membrane	IDA IDA: Inferred from direct assay	15207857	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SH3 and multiple ankyrin repeat domains protein 2	SH3/ankyrin domain gene 2 cortBP1 cortactin-binding protein 1

Shank2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Shank2	Q80Z38	Grid2	Mus musculus	Q61625	Pull Down	15207857
Intra	Shank2	Q80Z38	Grid2	Mus musculus	Q61625	Y2H	15207857
Intra	Shank2	Q80Z38	Caskin1	Mus musculus	Q6P9K8	Anti Bait CoIP	31727973

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12851	SHANK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shank2	NCBI	NCBI:22941