Dock10 - dedicator of cytokinesis 10 Gene

Also Known as Jr4; Jr5; ZIZ3; Zizimin3; mKIAA0694; 9330153B10Rik; A630054M16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 210293

Summary

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including dendritic spine morphogenesis; marginal zone B cell differentiation; and positive regulation of GTPase activity. Located in dendritic spine. Is expressed in several structures, including central nervous system; endocrine gland; retina; thymus primordium; and trigeminal nerve. Orthologous to human DOCK10 (dedicator of cytokinesis 10). [provided by Alliance of Genome Resources, Apr 2022]

Dock10 Products (4)

mRNA Protein Name
NM_001285927.2 NP_001272856.1 dedicator of cytokinesis protein 10 isoform 2
NM_001406554.1 NP_001393483.1 dedicator of cytokinesis protein 10 isoform 3
NM_001406555.1 NP_001393484.1 dedicator of cytokinesis protein 10 isoform 4
NM_175291.5 NP_780500.2 dedicator of cytokinesis protein 10 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
15710388 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
15710388 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell homeostasis IMP
IMP: Inferred from mutant phenotype
25729399 MGI
involved in dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
25851601 MGI
involved in marginal zone B cell differentiation IMP
IMP: Inferred from mutant phenotype
25729399 MGI
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
25851601 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
25851601 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
25851601 MGI
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
25851601 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25851601 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
25851601 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25851601 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
25851601 MGI
is active in postsynapse IEP
IEP: Inferred from expression pattern
25851601 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 10

  • zizimin-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03922 DOCK10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dock10 NCBI NCBI:55619