2. Gene
  3. DOCK10 - dedicator of cytokinesis 10 Gene

DOCK10 - dedicator of cytokinesis 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZIZ3; DRIP2; Nbla10300

Gene ID: 55619 | Gene type: protein coding

About DOCK10

Cytogenetic location: 2q36.2 Genomic coordinates (GRCh38): 2:224,765,090-225,042,468 (from NCBI)

This gene has 18 transcripts (splice variants), 233 orthologues and 10 paralogues. Broad expression in spleen (RPKM 10.3), lymph node (RPKM 9.4) and 22 other tissues.

Summary

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

DOCK10 Products(3)

mRNA Protein Name
NM_001290263.2 NP_001277192.1 dedicator of cytokinesis protein 10 isoform 2
NM_001363762.1 NP_001350691.1 dedicator of cytokinesis protein 10 isoform 3
NM_014689.3 NP_055504.2 dedicator of cytokinesis protein 10 isoform 1

DOCK10 Protein Structure

DUF3398

DUF3398: Domain of unknown function (DUF3398) (61 - 153)

PH

PH: PH domain (183 - 288)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (667 - 860)

DHR-2

DHR-2: Dock homology region 2 (1966 - 2142)

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  • 2186 a.a.
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 10

dopamine receptor interacting protein 2

Related Diseases

Diseases Alias
Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40
Ayme-Gripp Syndrome

AYGRP

Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation

Aymé-Gripp Syndrome

Fine-Lubinsky Syndrome

Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome

Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03922 DOCK10 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DOCK10 VGNC VGNC:28155
Canis familiaris DOCK10 VGNC VGNC:40044
Rattus norvegicus DOCK10 RGD RGD:1561963
Macaca mulatta DOCK10 VGNC VGNC:71888
Mus musculus DOCK10 MGD MGI:2146320
Felis catus DOCK10 VGNC VGNC:61570