DOCK10 - dedicator of cytokinesis 10 Gene

Also Known as ZIZ3; DRIP2; Nbla10300

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55619

About DOCK10

Cytogenetic location: 2q36.2 Genomic coordinates (GRCh38): 2:224,765,090-225,042,468 (from NCBI)

This gene has 18 transcripts (splice variants), 233 orthologues and 10 paralogues. Broad expression in spleen (RPKM 10.3), lymph node (RPKM 9.4) and 22 other tissues.

Summary

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

DOCK10 Products (3)

mRNA	Protein	Name
NM_001290263.2	NP_001277192.1	dedicator of cytokinesis protein 10 isoform 2
NM_001363762.1	NP_001350691.1	dedicator of cytokinesis protein 10 isoform 3
NM_014689.3	NP_055504.2	dedicator of cytokinesis protein 10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	18835169	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18499258	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18499258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK10 Protein Structure

DUF3398

PH

DOCK-C2

DHR-2

0
400
800
1200
1600
2000
2186 a.a.

Protein Preferred Names	Protein Names
dedicator of cytokinesis protein 10	dopamine receptor interacting protein 2

DOCK10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DOCK10	Q96BY6	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32814053
Intra	DOCK10	Q96BY6	SH3GLB1	Homo sapiens	Q9Y371	Y2H Array	32814053
Intra	DOCK10	Q96BY6	SH3GLB1	Homo sapiens	Q9Y371	Y2H Pooling	32814053
Intra	DOCK10	Q96BY6	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	DOCK10	Q96BY6	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 40	Dock2 Deficiency IMD40 Immunodeficiency, Type 40
Ayme-Gripp Syndrome	AYGRP Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation Aymé-Gripp Syndrome Fine-Lubinsky Syndrome Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03922	DOCK10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DOCK10	VGNC	VGNC:28155
Canis familiaris	DOCK10	VGNC	VGNC:40044
Rattus norvegicus	DOCK10	RGD	RGD:1561963
Macaca mulatta	DOCK10	VGNC	VGNC:71888
Mus musculus	DOCK10	MGD	MGI:2146320
Felis catus	DOCK10	VGNC	VGNC:61570
Others	DOCK10	NCBI