Themis - thymocyte selection associated Gene

Also Known as Gasp; Spot; Tsepa; thylex; E430004N04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 210757

Summary

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Themis Products (3)

mRNA Protein Name
NM_001305663.1 NP_001292592.1 protein THEMIS isoform 2
NM_001374699.1 NP_001361628.1 protein THEMIS isoform 4
NM_178666.6 NP_848781.1 protein THEMIS isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19597497 MGI
Biological Process GO Annotation Evidence References Source
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19597498 MGI
involved in negative T cell selection IMP
IMP: Inferred from mutant phenotype
19597498 MGI
involved in positive T cell selection IMP
IMP: Inferred from mutant phenotype
19597497 MGI
Cellular Component GO Annotation Evidence References Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
22561606 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19597497 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19597497 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein THEMIS

  • grb2-associating protein

  • signaling phosphoprotein specific for T cells

  • thymocyte selection pathway associated

  • thymocyte-expressed molecule involved in selection

  • thymus lymphocyte exclusively expressed

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14488 THEMIS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14489 THEMIS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Themis NCBI NCBI:387357