Mapre2 - microtubule-associated protein, RP/EB family, member 2 Gene

Also Known as EB1; EB2; RP1; D18Abb1e; C820009F03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 212307

Summary

Enables microtubule plus-end binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of ARF protein signal transduction; positive regulation of focal adhesion disassembly; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to human MAPRE2 (microtubule associated protein RP/EB family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Mapre2 Products (3)

mRNA Protein Name
NM_001162941.1 NP_001156413.1 microtubule-associated protein RP/EB family member 2 isoform 2
NM_001162942.1 NP_001156414.1 microtubule-associated protein RP/EB family member 2 isoform 3
NM_153058.4 NP_694698.3 microtubule-associated protein RP/EB family member 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule plus-end binding IDA
IDA: Inferred from direct assay
16148041 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16148041 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
25490267 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of ARF protein signal transduction IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of focal adhesion disassembly IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of keratinocyte migration IMP
IMP: Inferred from mutant phenotype
25490267 MGI
Cellular Component GO Annotation Evidence References Source
located in focal adhesion IDA
IDA: Inferred from direct assay
25490267 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microtubule-associated protein RP/EB family member 2

  • APC-binding protein EB1

  • APC-binding protein EB2

  • T-cell activation protein, EB1 family, member 2

  • end-binding protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08138 MAPRE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapre2 NCBI NCBI:10982