Slc39a14 - solute carrier family 39 (zinc transporter), member 14 Gene

Also Known as Zip14; ZIP-14; fad123; FAD-123

Species: Mus musculus

Gene Type: protein coding
Gene ID: 213053

Summary

Enables anion:cation symporter activity and transition metal ion transmembrane transporter activity. Involved in several processes, including negative regulation of cyclic-nucleotide phosphodiesterase activity; transition metal ion homeostasis; and transition metal ion transport. Acts upstream of or within iron ion transport and zinc ion transport. Located in basolateral plasma membrane. Is expressed in autopod; ear; face; nervous system; and skeleton. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 2. Orthologous to human SLC39A14 (solute carrier family 39 member 14). [provided by Alliance of Genome Resources, Apr 2022]

Slc39a14 Products (3)

mRNA Protein Name
NM_001135151.1 NP_001128623.1 metal cation symporter ZIP14 isoform a precursor
NM_001135152.1 NP_001128624.1 metal cation symporter ZIP14 isoform a precursor
NM_144808.4 NP_659057.2 metal cation symporter ZIP14 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cadmium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
18270315 MGI
enables ferrous iron transmembrane transporter activity IDA
IDA: Inferred from direct assay
16950869 MGI
enables iron ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
21653899 MGI
enables manganese ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
18270315 MGI
enables monoatomic anion:monoatomic cation symporter activity IDA
IDA: Inferred from direct assay
18270315 MGI
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
16950869 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IDA
IDA: Inferred from direct assay
27703010 MGI
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
27703010 MGI
acts upstream of chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
21445361 MGI
acts upstream of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
21445361 MGI
involved in inorganic cation transmembrane transport IDA
IDA: Inferred from direct assay
18270315 MGI
acts upstream of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27703010 MGI
involved in intracellular zinc ion homeostasis IMP
IMP: Inferred from mutant phenotype
21445361 MGI
involved in iron import into cell IMP
IMP: Inferred from mutant phenotype
20682781 MGI
involved in iron ion transmembrane transport IDA
IDA: Inferred from direct assay
21653899 MGI
involved in iron ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
20682781 MGI
acts upstream of or within iron ion transport IDA
IDA: Inferred from direct assay
16950869 MGI
involved in manganese ion homeostasis IMP
IMP: Inferred from mutant phenotype
28536273 MGI
involved in manganese ion transmembrane transport IDA
IDA: Inferred from direct assay
18270315 MGI
involved in positive regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21445361 MGI
acts upstream of regulation of hormone levels IMP
IMP: Inferred from mutant phenotype
21445361 MGI
involved in zinc ion transmembrane transport IDA
IDA: Inferred from direct assay
21653899 MGI
acts upstream of or within zinc ion transport IDA
IDA: Inferred from direct assay
16950869 MGI
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
28536273 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16950869 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metal cation symporter ZIP14

  • Zrt- and Irt-like protein 14

  • factor for adipocyte differentiation 123

  • zinc transporter ZIP14

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13233 SLC39A14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20674 Slc39a14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27185 Slc39a14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc39a14 NCBI NCBI:23516