Tarbp2 - TARBP2, RISC loading complex RNA binding subunit Gene

Mus musculus

Also known as Prbp; TRBP

Gene ID: 21357 | Gene type: protein coding

About Tarbp2

Summary

Predicted to enable several functions, including RNA binding activity; protein N-terminus binding activity; and protein homodimerization activity. Predicted to contribute to pre-miRNA binding activity. Acts upstream of or within several processes, including positive regulation of muscle cell differentiation; regulation of gene expression; and spermatid development. Part of RISC complex. Is expressed in brain and early embryo. Orthologous to human TARBP2 (TARBP2 subunit of RISC loading complex). [provided by Alliance of Genome Resources, Apr 2022]

Tarbp2 Products(2)

mRNA	Protein	Name
NM_001253795.1	NP_001240724.1	RISC-loading complex subunit TARBP2 isoform 2
NM_009319.3	NP_033345.2	RISC-loading complex subunit TARBP2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17452327	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	10369260	MGI
acts upstream of or within neural precursor cell proliferation	IDA IDA: Inferred from direct assay	28174252	MGI
acts upstream of or within positive regulation of muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	27159388	MGI
acts upstream of or within positive regulation of translation	IMP IMP: Inferred from mutant phenotype	10369260	MGI
acts upstream of or within regulation of miRNA processing	IMP IMP: Inferred from mutant phenotype	27159388	MGI
acts upstream of or within single fertilization	IMP IMP: Inferred from mutant phenotype	10369260	MGI
acts upstream of or within skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	27159388	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	10369260	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RISC complex	IDA IDA: Inferred from direct assay	22503104	MGI
part of RISC-loading complex	IPI IPI: Inferred from physical interaction	20211135	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

RISC-loading complex subunit TARBP2

PRM-1 RNA-binding protein	TAR (HIV) RNA binding protein 2
TAR RNA-binding protein 2	protamine-1 RNA-binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14207	TARBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tarbp2	NCBI	NCBI:6895

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