Tbl1x - transducin (beta)-like 1 X-linked Gene

Mus musculus

Also known as Tbl1; 5330429M20

Gene ID: 21372 | Gene type: protein coding

About Tbl1x

Summary

Enables chromatin binding activity; transcription cis-regulatory region binding activity; and transcription corepressor activity. Involved in positive regulation of transcription by RNA polymerase II and protein stabilization. Acts upstream of or within several processes, including fat cell differentiation; regulation of transcription, DNA-templated; and response to estrogen. Part of transcription regulator complex. Is expressed in cerebral cortex ventricular layer and genitourinary system. Human ortholog(s) of this gene implicated in Y-linked deafness 2 and congenital nongoitrous hypothyroidism 8. Orthologous to several human genes including TBL1X (transducin beta like 1 X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Tbl1x Products(1)

mRNA	Protein	Name
NM_020601.2	NP_065626.1	F-box-like/WD repeat-containing protein TBL1X

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14980219	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15728386	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14980219	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16127449	MGI
enables transcription corepressor activity	IMP IMP: Inferred from mutant phenotype	14980219	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within fat cell differentiation	IMP IMP: Inferred from mutant phenotype	14980219	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14980219	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16127449	MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	14980219	MGI
involved in protein stabilization	IDA IDA: Inferred from direct assay	26070566	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15728386	MGI
acts upstream of or within response to estrogen	IMP IMP: Inferred from mutant phenotype	14980219	MGI
acts upstream of or within response to steroid hormone	IMP IMP: Inferred from mutant phenotype	14980219	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15728386	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

F-box-like/WD repeat-containing protein TBL1X

transducin beta-like protein 1X

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168190	PROTAC TBL1X degrader-1		/	Unkown
HY-RS14261	TBL1X Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-168191	TBL1X ligand 1		/	Unkown
HY-168192	Thalidomide-NH-C4-amide-C3-Br		/	Unkown
HY-168193	5-Amino-N-(3-bromopropyl)pentanamide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tbl1x	NCBI	NCBI:6907

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