Tbl1x - transducin (beta)-like 1 X-linked Gene

Also Known as Tbl1; 5330429M20

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21372

Summary

Enables chromatin binding activity; transcription cis-regulatory region binding activity; and transcription corepressor activity. Involved in positive regulation of transcription by RNA polymerase II and protein stabilization. Acts upstream of or within several processes, including fat cell differentiation; regulation of transcription, DNA-templated; and response to estrogen. Part of transcription regulator complex. Is expressed in cerebral cortex ventricular layer and genitourinary system. Human ortholog(s) of this gene implicated in Y-linked deafness 2 and congenital nongoitrous hypothyroidism 8. Orthologous to several human genes including TBL1X (transducin beta like 1 X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Tbl1x Products (1)

mRNA Protein Name
NM_020601.2 NP_065626.1 F-box-like/WD repeat-containing protein TBL1X

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14980219 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15728386 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14980219 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16127449 MGI
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
14980219 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within fat cell differentiation IMP
IMP: Inferred from mutant phenotype
14980219 MGI
acts upstream of or within negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
14980219 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16127449 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
14980219 MGI
involved in protein stabilization IDA
IDA: Inferred from direct assay
26070566 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15728386 MGI
acts upstream of or within response to estrogen IMP
IMP: Inferred from mutant phenotype
14980219 MGI
acts upstream of or within response to steroid hormone IMP
IMP: Inferred from mutant phenotype
14980219 MGI
Cellular Component GO Annotation Evidence References Source
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15728386 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box-like/WD repeat-containing protein TBL1X

  • transducin beta-like protein 1X

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168190 PROTAC TBL1X degrader-1 / Unkown
HY-RS14261 TBL1X Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168191 TBL1X ligand 1 / Unkown
HY-168192 Thalidomide-NH-C4-amide-C3-Br / Unkown
HY-168193 5-Amino-N-(3-bromopropyl)pentanamide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbl1x NCBI NCBI:6907