Tbx4 - T-box 4 Gene

Also Known as 3930401C23

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21387

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including angiogenesis; embryonic limb morphogenesis; and lung development. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and limb primordium. Human ortholog(s) of this gene implicated in ischiocoxopodopatellar syndrome. Orthologous to human TBX4 (T-box transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Tbx4 Products (2)

mRNA Protein Name
NM_011536.3 NP_035666.2 T-box transcription factor TBX4 isoform a
NM_172798.1 NP_766386.1 T-box transcription factor TBX4 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16380715 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
12736212 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
12736212 MGI
acts upstream of or within limb morphogenesis IDA
IDA: Inferred from direct assay
15621531 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12508227 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
12508227 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-box transcription factor TBX4

  • T-box protein 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14280 TBX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbx4 NCBI NCBI:9496