2. Gene
  3. Tbx4 - T-box 4 Gene

Tbx4 - T-box 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 3930401C23

Gene ID: 21387 | Gene type: protein coding

About Tbx4

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including angiogenesis; embryonic limb morphogenesis; and lung development. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and limb primordium. Human ortholog(s) of this gene implicated in ischiocoxopodopatellar syndrome. Orthologous to human TBX4 (T-box transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Tbx4 Products(2)

mRNA Protein Name
NM_011536.3 NP_035666.2 T-box transcription factor TBX4 isoform a
NM_172798.1 NP_766386.1 T-box transcription factor TBX4 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16380715 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
12736212 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
12736212 MGI
acts upstream of or within limb morphogenesis IDA
IDA: Inferred from direct assay
15621531 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12508227 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
12508227 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-box transcription factor TBX4

T-box protein 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14280 TBX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tbx4 NCBI NCBI:9496