Agap3 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Gene

Also Known as Crag; Crag.; AGAP-3; Centg3; MRIP-1; cnt-g3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 213990

Summary

Enables GTPase activity and polyubiquitin modification-dependent protein binding activity. Acts upstream of or within cellular response to reactive oxygen species; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein import into nucleus. Located in cell periphery; cytoplasm; and nucleus. Orthologous to human AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Apr 2022]

Agap3 Products (3)

mRNA Protein Name
NM_001256431.1 NP_001243360.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b
NM_001359881.1 NP_001346810.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform 3
NM_139153.2 NP_631892.2 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
16461359 MGI
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
16461359 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to reactive oxygen species IDA
IDA: Inferred from direct assay
16461359 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16461359 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
16461359 MGI
Cellular Component GO Annotation Evidence References Source
located in cell periphery IDA
IDA: Inferred from direct assay
16461359 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16461359 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16461359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

  • CRAM-associated GTPase

  • MR1-interacting protein

  • centaurin, gamma 3

  • spidin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00439 AGAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Agap3 NCBI NCBI:116988