Agap3 - ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Gene

Mus musculus

Also known as Crag; Crag.; AGAP-3; Centg3; MRIP-1; cnt-g3

Gene ID: 213990 | Gene type: protein coding

About Agap3

Summary

Enables GTPase activity and polyubiquitin modification-dependent protein binding activity. Acts upstream of or within cellular response to reactive oxygen species; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein import into nucleus. Located in cell periphery; cytoplasm; and nucleus. Orthologous to human AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Apr 2022]

Agap3 Products(3)

mRNA	Protein	Name
NM_001256431.1	NP_001243360.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b
NM_001359881.1	NP_001346810.1	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform 3
NM_139153.2	NP_631892.2	arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	16461359	MGI
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	16461359	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to reactive oxygen species	IDA IDA: Inferred from direct assay	16461359	MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16461359	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	16461359	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell periphery	IDA IDA: Inferred from direct assay	16461359	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16461359	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16461359	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

CRAM-associated GTPase	MR1-interacting protein
centaurin, gamma 3	spidin

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00439	AGAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agap3	NCBI	NCBI:116988

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