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Tcf15 - transcription factor 15 Gene

Also Known as Meso1; bHLH-EC2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21407

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding activity; and bHLH transcription factor binding activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of stem cell differentiation; and stem cell population maintenance. Acts upstream of or within several processes, including animal organ development; epithelial cell differentiation; and post-anal tail morphogenesis. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including early embryo; foregut-midgut junction; genitourinary system; paraxial mesenchyme; and sensory organ. Orthologous to human TCF15 (transcription factor 15). [provided by Alliance of Genome Resources, Apr 2022]

Tcf15 Products (1)

mRNA	Protein	Name
NM_009328.2	NP_033354.2	transcription factor 15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18361414	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15226298	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	15226298	MGI
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18361414	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	15226298	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	8955271	MGI
acts upstream of or within ear development	IMP IMP: Inferred from mutant phenotype	8955271	MGI
acts upstream of or within establishment of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	24038871	MGI
acts upstream of or within mesenchymal to epithelial transition	IMP IMP: Inferred from mutant phenotype	24038871	MGI
acts upstream of or within muscle organ development	IMP IMP: Inferred from mutant phenotype	8955271	MGI
acts upstream of or within muscle organ morphogenesis	IMP IMP: Inferred from mutant phenotype	8955271	MGI
involved in negative regulation of hematopoietic stem cell differentiation	IDA IDA: Inferred from direct assay	32669716	MGI
acts upstream of or within neuromuscular process controlling posture	IMP IMP: Inferred from mutant phenotype	8955271	MGI
acts upstream of or within paraxial mesoderm development	IMP IMP: Inferred from mutant phenotype	8955271	MGI
involved in positive regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	23395635	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15226298	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	8955271	MGI
acts upstream of or within regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	24038871	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24038871	MGI
acts upstream of or within respiratory system process	IMP IMP: Inferred from mutant phenotype	8955271	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	8955271	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	8955271	MGI
involved in stem cell population maintenance	IDA IDA: Inferred from direct assay	32669716	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	18361414	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	23395635	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor 15	TCF-15 paraxis protein bHLH-EC2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14300	TCF15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tcf15	NCBI	NCBI:6939