Hnf1b - HNF1 homeobox B Gene

Also Known as LFB3; Tcf2; Tcf-2; vHNF1; HNF-1B; Hnf1beta; HNF-1Beta; HNF-1-beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21410

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of mesenchymal cell apoptotic process; regulation of transcription by RNA polymerase II; and tube morphogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B). [provided by Alliance of Genome Resources, Apr 2022]

Hnf1b Products (3)

mRNA Protein Name
NM_001291268.1 NP_001278197.1 hepatocyte nuclear factor 1-beta isoform 2
NM_001291269.1 NP_001278198.1 hepatocyte nuclear factor 1-beta isoform 3
NM_009330.3 NP_033356.2 hepatocyte nuclear factor 1-beta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
1363228 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
1673925 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20040500 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
1685988 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
1363228 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
1673925 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20040500 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
15872003 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
18635606 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
18635606 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
10518495 MGI
acts upstream of or within endodermal cell fate specification IMP
IMP: Inferred from mutant phenotype
18635606 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15647252 MGI
acts upstream of or within epithelium development IMP
IMP: Inferred from mutant phenotype
18635606 MGI
acts upstream of or within hepatoblast differentiation IMP
IMP: Inferred from mutant phenotype
18635606 MGI
acts upstream of or within hindbrain development IMP
IMP: Inferred from mutant phenotype
15872003 MGI
acts upstream of or within inner cell mass cell differentiation IMP
IMP: Inferred from mutant phenotype
10518496 MGI
acts upstream of or within insulin secretion IMP
IMP: Inferred from mutant phenotype
15142986 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within kidney morphogenesis IGI
IGI: Inferred from genetic interaction
23362348 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
18635606 MGI
acts upstream of mesenchymal cell apoptotic process involved in metanephros development IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within mesonephric duct development IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within mesonephric duct formation IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within mesonephric tubule development IGI
IGI: Inferred from genetic interaction
20040500 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18635606 MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process involved in metanephros development IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18635606 MGI
acts upstream of or within nephric duct development IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within nephric duct formation IMP
IMP: Inferred from mutant phenotype
19913010 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
1673925 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16274963 MGI
acts upstream of or within regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within regulation of branch elongation involved in ureteric bud branching IMP
IMP: Inferred from mutant phenotype
20040500 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
15142986 MGI
acts upstream of or within ureteric bud elongation IMP
IMP: Inferred from mutant phenotype
20040500 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
1363228 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
14570708 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte nuclear factor 1-beta

  • homeoprotein LFB3

  • transcription factor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06256 HNF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174668 Human HNF1B mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hnf1b NCBI NCBI:6928