Hnf1b - HNF1 homeobox B Gene

Mus musculus

Also known as LFB3; Tcf2; Tcf-2; vHNF1; HNF-1B; Hnf1beta; HNF-1Beta; HNF-1-beta

Gene ID: 21410 | Gene type: protein coding

About Hnf1b

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of mesenchymal cell apoptotic process; regulation of transcription by RNA polymerase II; and tube morphogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B). [provided by Alliance of Genome Resources, Apr 2022]

Hnf1b Products(3)

mRNA	Protein	Name
NM_001291268.1	NP_001278197.1	hepatocyte nuclear factor 1-beta isoform 2
NM_001291269.1	NP_001278198.1	hepatocyte nuclear factor 1-beta isoform 3
NM_009330.3	NP_033356.2	hepatocyte nuclear factor 1-beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	1363228	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	1673925	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20040500	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1685988	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	1363228	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	1673925	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	20040500	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15872003	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	18635606	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	18635606	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	10518495	MGI
acts upstream of or within endodermal cell fate specification	IMP IMP: Inferred from mutant phenotype	18635606	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15647252	MGI
acts upstream of or within epithelium development	IMP IMP: Inferred from mutant phenotype	18635606	MGI
acts upstream of or within hepatoblast differentiation	IMP IMP: Inferred from mutant phenotype	18635606	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	15872003	MGI
acts upstream of or within inner cell mass cell differentiation	IMP IMP: Inferred from mutant phenotype	10518496	MGI
acts upstream of or within insulin secretion	IMP IMP: Inferred from mutant phenotype	15142986	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within kidney morphogenesis	IGI IGI: Inferred from genetic interaction	23362348	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	18635606	MGI
acts upstream of mesenchymal cell apoptotic process involved in metanephros development	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within mesonephric duct development	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within mesonephric duct formation	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within mesonephric tubule development	IGI IGI: Inferred from genetic interaction	20040500	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18635606	MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process involved in metanephros development	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18635606	MGI
acts upstream of or within nephric duct development	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within nephric duct formation	IMP IMP: Inferred from mutant phenotype	19913010	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	1673925	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16274963	MGI
acts upstream of or within regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within regulation of branch elongation involved in ureteric bud branching	IMP IMP: Inferred from mutant phenotype	20040500	MGI
acts upstream of or within response to glucose	IMP IMP: Inferred from mutant phenotype	15142986	MGI
acts upstream of or within ureteric bud elongation	IMP IMP: Inferred from mutant phenotype	20040500	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	1363228	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	14570708	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 1-beta

homeoprotein LFB3

transcription factor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06256	HNF1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174668	Human HNF1B mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnf1b	NCBI	NCBI:6928

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