Cdk5rap2 - CDK5 regulatory subunit associated protein 2 Gene

Also Known as an; mKIAA1633; 2900018K03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214444

Summary

Predicted to enable several functions, including 14-3-3 protein binding activity; Calmodulin binding activity; and tubulin binding activity. Involved in several processes, including establishment of mitotic spindle orientation; negative regulation of centriole replication; and nervous system development. Located in centrosome and mitotic spindle pole. Is expressed in central nervous system and retina. Used to study microcephaly. Human ortholog(s) of this gene implicated in Seckel syndrome; microcephaly; and primary autosomal recessive microcephaly 3. Orthologous to several human genes including CDK5RAP2 (CDK5 regulatory subunit associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5rap2 Products (2)

mRNA Protein Name
NM_001313762.1 NP_001300691.1 CDK5 regulatory subunit-associated protein 2 isoform 2
NM_145990.4 NP_666102.2 CDK5 regulatory subunit-associated protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20471352 MGI
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
20460369 MGI
involved in establishment of mitotic spindle orientation IMP
IMP: Inferred from mutant phenotype
20460369 MGI
involved in negative regulation of centriole replication IMP
IMP: Inferred from mutant phenotype
20627074 MGI
involved in negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
20471352 MGI
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
20460369 MGI
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
17920017 MGI
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
25220058 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CDK5 regulatory subunit-associated protein 2

  • CDK5 activator-binding protein C48

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02390 CDK5RAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk5rap2 NCBI NCBI:55755