2. Gene
  3. Tcof1 - treacle ribosome biogenesis factor 1 Gene

Tcof1 - treacle ribosome biogenesis factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as treacle

Gene ID: 21453 | Gene type: protein coding

About Tcof1

Summary

Predicted to enable protein heterodimerization activity; protein-macromolecule adaptor activity; and scaffold protein binding activity. Acts upstream of or within nucleolar large rRNA transcription by RNA polymerase I. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in nucleolus. Is expressed in several structures, including appendicular skeleton; branchial arch; facial prominence; genitourinary system; and neural ectoderm. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome and Treacher Collins syndrome 1. Orthologous to human TCOF1 (treacle ribosome biogenesis factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Tcof1 Products(2)

mRNA Protein Name
NM_001198984.1 NP_001185913.1 treacle protein isoform 1
NM_011552.3 NP_035682.1 treacle protein isoform 2
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within nucleolar large rRNA transcription by RNA polymerase I IMP
IMP: Inferred from mutant phenotype
15249688 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

treacle protein

Treacher Collins Franceschetti syndrome 1, homolog

treacher Collins syndrome protein homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-145269 AL-GDa62 Inhibitor / Unkown
HY-RS14320 TCOF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tcof1 NCBI NCBI:6949