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Spg11 - SPG11, spatacsin vesicle trafficking associated Gene

Also Known as A330015I11; 6030465E24Rik; C530005A01Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 214585

Summary

Acts upstream of or within several processes, including axonogenesis; Cholesterol efflux; and motor neuron apoptotic process. Located in several cellular components, including axon; cytosol; and dendrite. Used to study hereditary spastic paraplegia 11. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2X; amyotrophic lateral sclerosis type 5; and hereditary spastic paraplegia 11. Orthologous to human SPG11 (SPG11 vesicle trafficking associated, spatacsin). [provided by Alliance of Genome Resources, Apr 2022]

Spg11 Products (1)

mRNA	Protein	Name
NM_145531.2	NP_663506.2	spatacsin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	37871017	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axo-dendritic transport	IMP IMP: Inferred from mutant phenotype	24794856	MGI
acts upstream of or within axon extension	IMP IMP: Inferred from mutant phenotype	24794856	MGI
acts upstream of or within cholesterol efflux	IMP IMP: Inferred from mutant phenotype	28237315	MGI
acts upstream of or within corticospinal tract morphogenesis	IMP IMP: Inferred from mutant phenotype	28237315	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	37871017	MGI
acts upstream of or within localization within membrane	IMP IMP: Inferred from mutant phenotype	31637311	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	26284655	MGI
acts upstream of or within memory	IMP IMP: Inferred from mutant phenotype	28237315	MGI
acts upstream of or within motor behavior	IMP IMP: Inferred from mutant phenotype	28237315	MGI
acts upstream of or within motor neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	28237315	MGI
acts upstream of or within neuromuscular junction development	IMP IMP: Inferred from mutant phenotype	28237315	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	28237315	MGI
acts upstream of or within phagosome-lysosome fusion involved in apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	26284655	MGI
acts upstream of or within protein catabolic process	IMP IMP: Inferred from mutant phenotype	37871017	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	31637311	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	37871017	MGI
acts upstream of or within regulation of store-operated calcium entry	IMP IMP: Inferred from mutant phenotype	31637311	MGI
acts upstream of or within skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	28237315	MGI
acts upstream of or within vesicle transport along microtubule	IMP IMP: Inferred from mutant phenotype	37871017	MGI
acts upstream of or within walking behavior	IMP IMP: Inferred from mutant phenotype	26284655	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	24794856	MGI
located in cytosol	IDA IDA: Inferred from direct assay	24794856	MGI
located in dendrite	IDA IDA: Inferred from direct assay	24794856	MGI
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	37871017	MGI
located in synapse	IMP IMP: Inferred from mutant phenotype	24794856	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
spatacsin	spastic paraplegia 11 protein homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13661	SPG11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spg11	NCBI	NCBI:80208