Sidt2 - SID1 transmembrane family, member 2 Gene

Also Known as CGI-40; B930096O19

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214597

Summary

Enables several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and double-stranded RNA binding activity. Involved in RNA catabolic process and RNA transport. Acts upstream of or within several processes, including regulation of Insulin secretion involved in cellular response to glucose stimulus; type B pancreatic cell development; and type B pancreatic cell proliferation. Located in lysosomal membrane and plasma membrane. Is expressed in several structures, including inner ear; submandibular gland primordium; and vibrissa. Used to study non-alcoholic fatty liver disease. Orthologous to human SIDT2 (SID1 transmembrane family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Sidt2 Products (3)

mRNA Protein Name
NM_001289668.1 NP_001276597.1 SID1 transmembrane family member 2 isoform 1 precursor
NM_001359653.1 NP_001346582.1 SID1 transmembrane family member 2 isoform 3 precursor
NM_172257.4 NP_758461.1 SID1 transmembrane family member 2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables AP-1 adaptor complex binding IDA
IDA: Inferred from direct assay
28724756 MGI
enables AP-2 adaptor complex binding IDA
IDA: Inferred from direct assay
28724756 MGI
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
26067272 MGI
enables nucleic acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
27046251 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
27046251 MGI
Biological Process GO Annotation Evidence References Source
involved in RNA catabolic process IDA
IDA: Inferred from direct assay
27046251 MGI
involved in RNA transport IDA
IDA: Inferred from direct assay
27046251 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
23776622 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
23776622 MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
23776622 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
23776622 MGI
acts upstream of or within type B pancreatic cell development IMP
IMP: Inferred from mutant phenotype
23776622 MGI
acts upstream of or within type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
23776622 MGI
Cellular Component GO Annotation Evidence References Source
located in lysosomal membrane IDA
IDA: Inferred from direct assay
20965152 MGI
located in lysosome IDA
IDA: Inferred from direct assay
27046251 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
28277980 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SID1 transmembrane family member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12895 SIDT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sidt2 NCBI NCBI:51092