L3mbtl2 - L3MBTL2 polycomb repressive complex 1 subunit Gene

Also Known as M4mbt; 4732493N06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214669

Summary

Enables promoter-specific chromatin binding activity. Acts upstream of or within several processes, including ectoderm development; regulation of histone modification; and stem cell proliferation. Located in nucleus. Is expressed in several structures, including blastocyst; early embryo; genitourinary system; gut; and immune system. Orthologous to human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

L3mbtl2 Products (3)

mRNA Protein Name
NM_001289711.1 NP_001276640.1 lethal(3)malignant brain tumor-like protein 2 isoform 1
NM_001289712.1 NP_001276641.1 lethal(3)malignant brain tumor-like protein 2 isoform 3
NM_145993.5 NP_666105.2 lethal(3)malignant brain tumor-like protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22770845 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22770845 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromatin organization IMP
IMP: Inferred from mutant phenotype
22770845 MGI
acts upstream of or within ectoderm development IMP
IMP: Inferred from mutant phenotype
22770845 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22770845 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
22770845 MGI
acts upstream of or within stem cell proliferation IDA
IDA: Inferred from direct assay
22770845 MGI
acts upstream of or within stem cell proliferation IMP
IMP: Inferred from mutant phenotype
22770845 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14597177 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lethal(3)malignant brain tumor-like protein 2

  • l(3)mbt-like 2

  • l(3)mbt-like protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07485 L3MBTL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens L3mbtl2 NCBI NCBI:83746