L3mbtl2 - L3MBTL2 polycomb repressive complex 1 subunit Gene

Mus musculus

Also known as M4mbt; 4732493N06Rik

Gene ID: 214669 | Gene type: protein coding

About L3mbtl2

Summary

Enables promoter-specific chromatin binding activity. Acts upstream of or within several processes, including ectoderm development; regulation of histone modification; and stem cell proliferation. Located in nucleus. Is expressed in several structures, including blastocyst; early embryo; genitourinary system; gut; and immune system. Orthologous to human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

L3mbtl2 Products(3)

mRNA	Protein	Name
NM_001289711.1	NP_001276640.1	lethal(3)malignant brain tumor-like protein 2 isoform 1
NM_001289712.1	NP_001276641.1	lethal(3)malignant brain tumor-like protein 2 isoform 3
NM_145993.5	NP_666105.2	lethal(3)malignant brain tumor-like protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22770845	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22770845	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within chromatin organization	IMP IMP: Inferred from mutant phenotype	22770845	MGI
acts upstream of or within ectoderm development	IMP IMP: Inferred from mutant phenotype	22770845	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22770845	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	22770845	MGI
acts upstream of or within stem cell proliferation	IDA IDA: Inferred from direct assay	22770845	MGI
acts upstream of or within stem cell proliferation	IMP IMP: Inferred from mutant phenotype	22770845	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	14597177	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lethal(3)malignant brain tumor-like protein 2

l(3)mbt-like 2

l(3)mbt-like protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07485	L3MBTL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	L3mbtl2	NCBI	NCBI:83746

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