Mmp21 - matrix metallopeptidase 21 Gene

Mus musculus

Also known as b2b873Clo; b2b2458Clo

Gene ID: 214766 | Gene type: protein coding

About Mmp21

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. Mice harboring certain mutations in this gene exhibit congenital heart defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

Mmp21 Products(2)

mRNA	Protein	Name
NM_001320216.1	NP_001307145.1	matrix metalloproteinase-21 isoform 2 precursor
NM_152944.1	NP_694423.1	matrix metalloproteinase-21 isoform 1 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in determination of heart left/right asymmetry	IMP IMP: Inferred from mutant phenotype	26437028	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	25807483	MGI
involved in determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	26437028	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IGI IGI: Inferred from genetic interaction	24029230	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

matrix metalloproteinase-21

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08541	MMP21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mmp21	NCBI	NCBI:118856

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