Vezt - vezatin, adherens junctions transmembrane protein Gene

Also Known as A630071D13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 215008

Summary

This gene encodes a transmembrane protein that is essential for the formation of adherens junctions. It is required for both the pre-implantation morphogenesis of a blastocyst and for the implantation process. The encoded protein is also a component of the ankle-link complex in cochlear hair cells, where it may effect resilience to sound trauma. It is also thought to be involved in dendritic spine morphogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Vezt Products (4)

mRNA Protein Name
NM_001304572.1 NP_001291501.1 vezatin isoform 2
NM_001304575.1 NP_001291504.1 vezatin isoform 3
NM_001304720.1 NP_001291649.1 vezatin isoform 4
NM_172538.5 NP_766126.2 vezatin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17567809 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
16199027 MGI
acts upstream of or within chordate embryonic development IMP
IMP: Inferred from mutant phenotype
16199027 MGI
involved in synapse maturation IDA
IDA: Inferred from direct assay
22745500 MGI
involved in synapse maturation IMP
IMP: Inferred from mutant phenotype
22745500 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34642320 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16199027 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16199027 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
22745500 MGI
part of stereocilia ankle link complex IDA
IDA: Inferred from direct assay
17567809 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vezatin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15642 VEZT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vezt NCBI NCBI:55591