Vgll2 - vestigial like family member 2 Gene

Also Known as Vito1; vgl-2; VITO-1; C130057C21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 215031

Summary

This gene is a member of the Vestigial-like (Vgl) gene family and is upregulated during muscle differentiation. The product of this gene interacts with and modifies the DNA-binding properties of the transcription factor, TEF-1, and is important for muscle tissue development. Reduced expression of this gene leads to a reduction in the terminal differentiation of muscle cells. Alternate splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]

Vgll2 Products (2)

mRNA Protein Name
NM_001300957.1 NP_001287886.1 transcription cofactor vestigial-like protein 2 isoform 2
NM_153786.2 NP_722481.1 transcription cofactor vestigial-like protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12376544 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
12376544 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12376544 MGI
acts upstream of or within skeletal muscle tissue development IDA
IDA: Inferred from direct assay
14762206 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12376544 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12376544 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription cofactor vestigial-like protein 2

  • vestigial like 2 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15645 VGLL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vgll2 NCBI NCBI:245806